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Rabbit anti-ATR Antibody, Affinity Purified

Name: Rabbit anti-ATR Antibody, Affinity Purified
Brand: SIGMA
Price: 540 USD

Powered by Bethyl Laboratories, Inc.

Synonym(s):

FCTCS, FRAP-related protein 1, FRAP-related protein-1, FRP1, MEC1, SCKL, SCKL1, ataxia telangiectasia and Rad3 related, ataxia telangiectasia and Rad3-related protein, homolog, homolog (S. cerevisiae), mitosis entry checkpoint 1

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Size/SKU	Availability	Price
100 μL	Check Cart for Availability	$540.00

About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IP, WB

Citations:

$540.00

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Properties

biological source

rabbit

Quality Segment

100

conjugate

unconjugated

antibody form

affinity purified immunoglobulin

antibody product type

primary antibodies

clone

polyclonal

species reactivity

human

technique(s)

immunoprecipitation (IP): 2- 5 μg/mg, western blot: 1:2,000-1:10,000

accession no.

NP_001175.1

UniProt accession no.

Q13535

shipped in

wet ice

storage temp.

2-8°C

target post-translational modification

unmodified

Gene Information

rabbit ... ATR(545)

Description

General description

Ataxia telangiectasia and Rad3-related protein (ATR), a serine/threonine kinase, is a member of the phosphoinositide 3- kinase-related protein kinase s (PIKKs) family mainly to ataxia telangiectasia mutated (ATM) subfamily. It has a phosphatidylinositol 3/4 (PI3/4) kinase catalytic domain, 1 focal adhesion kinase, targeting (FAT) domain, 1 FATC domain, 1 UME domain, and 2 HEAT repeats. ATR has ATR-201 and ATR-202 isoforms. Isoform 1 is expressed at a high level in the testis. Isoform 2 is expressed in the pancreas, liver and, placenta. The ATR gene is located on human chromosome 3q23.

Immunogen

The epitope recognized by PLA0046 maps to a region between residues 1675 and 1725 of human Ataxia Telangiectasia and Rad3-related using the numbering given in entry NP_001175.1 (GeneID 545).

Biochem/physiol Actions

Ataxia-telangiectasia and Rad3-related protein (ATR) plays a key role in maintaining the integrity of the genome. It participates in stabilizing replication forks and modulates the cell cycle progression and DNA repair. ATR plays a vital role in cell viability. It sends out signals to control replication origin firing, replication fork repair, and mitotic entry prematurely. Lack of ATR affects normal development, aging, and tissue homeostasis. Mutation in the ATR gene is associated with Seckel syndrome.

Physical form

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide

Other Notes

ATR (ATM and Rad3 related) is closely related to ATM (Ataxia telangiectasia, mutated) and is a member of the phosphatidylinositol 3 kinase (PI-3) family that is an early sensor of DNA damage. ATR is a serine-threonine kinase that reacts to UV damage and interruptions in replication. ATR may be able to sense DNA damage through interaction with Rad17 and 1as well as components of nucleosome remodeling complexes. In response to DNA damage, ATR has been shown to phosphorylate a multitude of substrates which include BRCA1, p53, Chk2, Rad 17, and E2F transcription factor 1.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	WH0000545M1	SAB1403593	PLA0105
Sigma-Aldrich PLA0046 Rabbit anti-ATR Antibody, Affinity Purified	Sigma-Aldrich WH0000545M1 Monoclonal Anti-ATR antibody produced in mouse	Sigma-Aldrich SAB1403593 Monoclonal Anti-ATR, (C-terminal) antibody produced in mouse	Sigma-Aldrich PLA0105 Rabbit anti-XRN1 Antibody, Affinity Purified
description Powered by Bethyl Laboratories, Inc.	description clone 3F2, purified immunoglobulin, buffered aqueous solution	description clone 1E9, purified immunoglobulin, buffered aqueous solution	description Powered by Bethyl Laboratories, Inc.
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
species reactivity human	species reactivity human	species reactivity human	species reactivity mouse, human
antibody form affinity purified immunoglobulin	antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form affinity purified immunoglobulin
biological source rabbit	biological source mouse	biological source mouse	biological source rabbit
clone polyclonal	clone 3F2, monoclonal	clone 1E9, monoclonal	clone polyclonal
storage temp. 2-8°C	storage temp. −20°C	storage temp. −20°C	storage temp. 2-8°C

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Storage Class

12 - Non Combustible Liquids

WGK

nwg

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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