Key Documents

Anti-VISA (ab1) antibody produced in rabbit

Name: Anti-VISA (ab1) antibody produced in rabbit
Brand: SIGMA
Price: 580 USD
Availability: InStock

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-CARD adapter inducing interferon-beta, Anti-MAVS, Anti-Mmitochondrial antiviral signaling protein, Anti-Virus-induced signaling adapter

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Size/SKU	Availability	Price
100 μg	Usually ships in 5 business days. (Orders outside of US, please allow an additional 1-2 weeks for delivery)	$580.00

About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ELISA (i), IF, IHC, WB

Citations:

$580.00

Usually ships in 5 business days. (Orders outside of US, please allow an additional 1-2 weeks for delivery)

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Properties

biological source

rabbit

Quality Segment

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse, human, rat

technique(s)

immunofluorescence: suitable, immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable

UniProt accession no.

Q7Z434

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MAVS(57506)

Description

General description

VISA (virus-induced signalling adaptor) is also designated as MAVS (mitochondrial antiviral signalling protein). It has 540 amino acids and three main domains such as N-terminal caspase recruitment and activation domain (CARD), an internal proline-rich region and a C-terminal transmembrane (TM) domain. It is mapped to chromosome 20p13. It is intermediately expressed in all tissues and brain regions except in fetal brain.

Immunogen

a 13 amino acid peptide from near the amino-terminus of human VISA.

Biochem/physiol Actions

VISA (virus-induced signalling adaptor) serves as an adaptor molecule for retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs). It activates intracellular signaling cascades, that leads to nuclear translocation of the transcription factors- IRF3 (interferon regulatory factor 3), IRF7 (interferon regulatory factor 7), and NF-κB (Nuclear factor-κB). It also helps in the formation of type I interferons (IFN-I) and proinflammatory cytokines.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Other Notes

The action of this antibody can be blocked using blocking peptide SBP4053.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	HPA049850	HPA018506	PRS3941
Sigma-Aldrich PRS4053 Anti-VISA (ab1) antibody produced in rabbit	Sigma-Aldrich HPA049850 Anti-MAVS antibody produced in rabbit	Sigma-Aldrich HPA018506 Anti-SIT1 antibody produced in rabbit	Sigma-Aldrich PRS3941 Anti-IRF7 (ab1) antibody produced in rabbit
description affinity isolated antibody, buffered aqueous solution	description Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution	description Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution	description affinity isolated antibody, buffered aqueous solution
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
form buffered aqueous solution	form buffered aqueous glycerol solution	form buffered aqueous glycerol solution	form buffered aqueous solution
shipped in dry ice	shipped in wet ice	shipped in wet ice	shipped in dry ice

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Storage Class

10 - Combustible liquids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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