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R109

Ro 15-4513

solid

Synonym(s):

Ethyl 8-azido-6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate, Ro15-4513

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Size/SKUAvailabilityPrice
100 mg
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$1,600.00

About This Item

Empirical Formula (Hill Notation):
C15H14N6O3
CAS Number:
91917-65-6
Molecular Weight:
326.31
NACRES:
NA.77
PubChem Substance ID:
24899343
UNSPSC Code:
12352200
MDL number:
MFCD00078598
Form:
solid

$1,600.00

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form

solid

Quality Segment

100

color

tan

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.8 mg/mL, H2O: insoluble, methanol: soluble

originator

Roche

SMILES string

CCOC(=O)c1ncn-2c1CN(C)C(=O)c3cc(ccc-23)N=[N+]=[N-]

InChI

1S/C15H14N6O3/c1-3-24-15(23)13-12-7-20(2)14(22)10-6-9(18-19-16)4-5-11(10)21(12)8-17-13/h4-6,8H,3,7H2,1-2H3

InChI key

CFSOJZTUTOQNIA-UHFFFAOYSA-N

Gene Information

human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA5(2558), GABRA6(2559)
rat ... Gabrg1(140674)

Application

Ro 15-4513 has been used as a benzodiazepine (Bz) inverse agonist in rats and to test its binding with diazepam-sensitive (DS) receptors in in vitro radioligand binding studies.

Biochem/physiol Actions

Ro 15-4513 is benzodiazepine receptor partial inverse agonist. It elicits anxiogenic property and is an ethanol antagonist. It elicits a high affinity towards diazepam sensitive and insensitive sites in the cerebellar region. Ro 15-4513 possesses an imidazo ring and is an imidazobenzodiazepine.

Features and Benefits

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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1 of 1

This Item
M227Z103C5174
Ro 15-4513 solid

Sigma-Aldrich

R109

Ro 15-4513

MRS 1191 solid

Sigma-Aldrich

M227

MRS 1191

Zolpidem ≥98% (HPLC), solid

Sigma-Aldrich

Z103

Zolpidem

4′-Chlorodiazepam ≥98% (TLC)

Sigma-Aldrich

C5174

4′-Chlorodiazepam

description

solid

description

solid

description

≥98% (HPLC), solid

description

≥98% (TLC)

form

solid

form

solid

form

solid

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

200

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.8 mg/mL, methanol: soluble, H2O: insoluble

solubility

DMSO: >10 mg/mL, ethanol: >10 mg/mL, H2O: insoluble

solubility

45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.3 mg/mL, DMSO: >10 mg/mL, ethanol: 50 mg/mL, methanol: 50 mg/mL, H2O: insoluble, dilute aqueous base: insoluble

solubility

2-hydroxypropyl-β-cyclodextrin: insoluble, H2O: insoluble

color

tan

color

white

color

white

color

-

Gene Information

human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA5(2558), GABRA6(2559)
rat ... Gabrg1(140674)

Gene Information

-

Gene Information

human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRG2(2566)
rat ... Gabra1(29705), Gabra2(29706), Gabra5(29707), Tspo(24230)

Gene Information

rat ... Tspo(24230)

originator

Roche

originator

-

originator

Sanofi Aventis

originator

-

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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