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Monoclonal Anti-Ryanodine Receptor antibody produced in mouse

Name: Monoclonal Anti-Ryanodine Receptor antibody produced in mouse
Brand: SIGMA
Price: 696 USD
Availability: InStock

clone C3-33, ascites fluid

Synonym(s):

Anti-CCO, Anti-KDS, Anti-MHS, Anti-MHS1, Anti-PPP1R137, Anti-RYDR, Anti-RYR, Anti-RYR-1, Anti-SKRR

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Size/SKU	Availability	Price
100 μg	Check Cart for Availability	$696.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD00282461

Conjugate:

unconjugated

Clone:

C3-33, monoclonal

Application:

IHC (f), IP, WB CL

Citations:

$696.00

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Properties

Quality Segment

200

biological source

mouse

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

C3-33, monoclonal

mol wt

antigen ~565 kDa (non-mammalian vertebrates, a doublet at 565 kDa represents the α and β isoforms)

species reactivity

canine, rabbit, rat, chicken, amphibian, guinea pig, mouse, fish, human

concentration

~1 mg/mL

technique(s)

immunohistochemistry (frozen sections): 1 μg/mL using 4% paraformaldehyde-fixed, frozen mouse brain tissue, immunoprecipitation (IP): suitable, western blot (chemiluminescent): 1 μg/mL

isotype

IgG1

UniProt accession no.

P21817

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

rat ... Ryr1(114207), Ryr2(84025)

Description

General description

RyR1 (ryanodine receptor isoform 1) is a homotetrameric intracellular calcium channel, that is present in skeletal muscle tissue. It is located on human chromosome 19q13.1. In rats, RyR1 and RyR2 are expressed in PASMCs (pulmonary artery smooth muscle cells).

Immunogen

dog cardiac ryanodine receptors (RyR)

Application

Anti-Ryanodine Receptor has been used in immunofluorescence assay.

Biochem/physiol Actions

In rats PASMCs (pulmonary artery smooth muscle cells), RyR2 (ryanodine receptor isoform 1) participates in RyR-gated Ca²⁺ entry. It controls the secretion of insulin and glucose homeostasis. After hemorrhagic shock, RyR2 involves in the progress of vascular bi-phasic reactivity to NE (norepinephrine). In human, RyR1 plays an important role in muscle contraction. RYR1 mutation causes CCD (central core disease) and MHS (malignant hyperthermia susceptibility).

The antibody reacts strongly with RyR-2 (expressed predominantly in the heart muscle, but also found in stomach, endothelial cells and diffuse areas of the brain; also known as the β isoform), and weakly with RyR-1 (expressed predominantly in skeletal muscle and areas of the brain; also known as the α isoform). It reacts with ryanodine receptor in cardiac muscle of canine, rat, finch and pigeon; in visceral smooth muscle of toad; and in rat brain. It reacts with skeletal muscle of fish and the β isoform of frog, but only weakly with skeletal muscle in rabbit and the α isoform of frog. In immunohistochemistry, the antibody stains are consistent with the endoplasmic reticulum localization of the receptor in the hippocampus.

Physical form

Containing PBS and 0.05% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	R129	ZRB2525	ZRB1466
Sigma-Aldrich R128 Monoclonal Anti-Ryanodine Receptor antibody produced in mouse	Sigma-Aldrich R129 Monoclonal Anti-Ryanodine Receptor antibody produced in mouse	ZRB2525 Anti-RYR1 Antibody, clone 1K4 ZooMAb^® Rabbit Monoclonal	Sigma-Aldrich ZRB1466 Anti-Ryanodine Receptor 2 Antibody, clone 2K6 ZooMAb^® Rabbit Monoclonal
description clone C3-33, ascites fluid	description clone 34C, ascites fluid	description recombinant, expressed in HEK 293 cells	description recombinant, expressed in HEK 293 cells
Gene Information rat ... Ryr1(114207), Ryr2(84025)	Gene Information human ... RYR1(6261), RYR2(6262) mouse ... Ryr1(20190), Ryr2(20191) rat ... Ryr1(114207), Ryr2(84025)	Gene Information human ... RYR1(6261)	Gene Information -
clone C3-33, monoclonal	clone 34C, monoclonal	clone 1K4, recombinant monoclonal	clone 2K6, recombinant monoclonal
species reactivity canine, rabbit, rat, chicken, amphibian, guinea pig, mouse, fish, human	species reactivity human, rat, rabbit, canine, mink, bovine, frog, fish, primate, chicken, mouse, sheep	species reactivity mouse, human	species reactivity human
biological source mouse	biological source mouse	biological source rabbit	biological source rabbit
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form ascites fluid	antibody form ascites fluid	antibody form purified antibody	antibody form purified antibody

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Storage Class

10 - Combustible liquids

WGK

nwg

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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