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Anti-hnRNP-L antibody, Mouse monoclonal

Name: Anti-hnRNP-L antibody, Mouse monoclonal
Brand: SIGMA
Price: 700 USD
Availability: InStock

clone 4D11, purified from hybridoma cell culture

Synonym(s):

Anti-Heterogeneous Nuclear Ribonucleoprotein-L

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Size/SKU	Availability	Price
200 μL	Check Cart for Availability	$700.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD03845440

Conjugate:

unconjugated

Clone:

4D11, monoclonal

Application:

ARR, ELISA (i), ICC, IP, WB

Citations:

$700.00

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Properties

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

4D11, monoclonal

form

buffered aqueous solution

mol wt

antigen ~68 kDa

species reactivity

bovine, newt, chicken, human, monkey, mouse

technique(s)

immunocytochemistry: suitable, immunoprecipitation (IP): suitable, indirect ELISA: suitable, microarray: suitable, western blot: 0.25-0.5 μg/mL using total cell extract of MDBK cells

isotype

IgG1

UniProt accession no.

P14866

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... HNRNPL(3191)
mouse ... Hnrnpl(15388)

Description

General description

Monoclonal Anti-hnRNP-L (mouse IgG1 isotype) is derived from the 4D11 hybridoma produced by the fusion of mouse myeloma cells (SP2/0 cells) and splenocytes from BALA/c mice immunized with hnRNP proteins and purified by affinity chromatography on ssDNA-agarose. RNA polymerase II transcripts in the nucleus are in complex with several proteins called heterogeneous nuclear ribonucleoproteins (hnRNPs). hnRNPs consist of protein groups named A to U and many of these protein groups consist of more than one isoform. Group L and M are one of the most abundant groups of proteins.

Immunogen

hnRNP proteins.

Application

Anti-hnRNP-L antibody has been used in

immunoblotting
enzyme linked immunosorbent assay (ELISA)
immunoprecipitation
immunocytochemistry
western blotting

Biochem/physiol Actions

Heterogeneous nuclear ribonucleoproteins-L (hnRNP-L) is involved in splicing regulations, internal translation initiation of hepatitis C virus (HCV), stability of the human vascular endothelial growth factor (VEGF) mRNA under hypoxic growth conditions, and intron independent mRNA export.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, and 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	R5028	R4528	R6278
Sigma-Aldrich R4903 Anti-hnRNP-L antibody, Mouse monoclonal	Sigma-Aldrich R5028 Monoclonal Anti-hnRNP-C1/C2 antibody produced in mouse	Sigma-Aldrich R4528 Anti-hnRNP-A1 antibody, Mouse monoclonal	Sigma-Aldrich R6278 Anti-hnRNP-U antibody, Mouse monoclonal
description clone 4D11, purified from hybridoma cell culture	description clone 4F4, purified immunoglobulin, buffered aqueous solution	description clone 9H10, purified from hybridoma cell culture	description clone 3G6, purified from hybridoma cell culture
species reactivity bovine, newt, chicken, human, monkey, mouse	species reactivity monkey, human, chicken, hamster	species reactivity human, hamster, monkey, rat, bovine, mouse, canine	species reactivity human, monkey
biological source mouse	biological source mouse	biological source mouse	biological source mouse
Gene Information human ... HNRNPL(3191) mouse ... Hnrnpl(15388)	Gene Information human ... HNRNPC(3183)	Gene Information human ... HNRNPA1(3178) mouse ... Hnrnpa1(15382) rat ... Hnrnpa1(29578)	Gene Information human ... HNRNPU(3192)
antibody form purified from hybridoma cell culture	antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form purified from hybridoma cell culture
clone 4D11, monoclonal	clone 4F4, monoclonal	clone 9H10, monoclonal	clone 3G6, monoclonal
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated

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Storage Class

10 - Combustible liquids

WGK

nwg

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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