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Monoclonal Anti-hnRNP-C1/C2 antibody produced in mouse

Name: Monoclonal Anti-hnRNP-C1/C2 antibody produced in mouse
Brand: SIGMA
Price: 725 USD
Availability: InStock

clone 4F4, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-Heterogeneous Nuclear Ribonucleoprotein-C1/C2

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Size/SKU	Availability	Price
200 μL	Check Cart for Availability	$725.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD06798703

Conjugate:

unconjugated

Clone:

4F4, monoclonal

Application:

ARR, ELISA (i), ICC, IP, WB

Citations:

$725.00

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Properties

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

4F4, monoclonal

form

buffered aqueous solution

mol wt

antigen 41 kDa, antigen 43 kDa

species reactivity

monkey, human, chicken, hamster

technique(s)

immunocytochemistry: suitable, immunoprecipitation (IP): suitable, indirect ELISA: suitable, microarray: suitable, western blot: 0.1-0.2 μg/mL using HeLa cell nuclear extract

isotype

IgG1

UniProt accession no.

P07910

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... HNRNPC(3183)

Description

General description

Monoclonal Anti-hnRNP-C1/C2 (mouse IgG1isotype) is derived from the 4F4 hybridoma produced by the fusion of mouse myeloma cells (SP2/0 cells) and splenocytes from BALB/c mice immunized with RNPs eluted from oligo (dT) cellulose column. Heterogeneous nuclear ribonucleoproteins C1/C2 (HnRNP C1/C2) are synthesized from C2 protein by alternative splicing and have an additional13-amino-acids. It is localized in nucleus and has leucine zipper-like RNA-binding motif. The hnRNP-C proteins have a single ribonucleoprotein (RNP) motif RNA-binding domain (RBD) of 80 to 100 amino acid long.

Immunogen

RNPs eluted from oligo (dT) cellulose column.

Application

Monoclonal Anti-hnRNP-C1/C2 antibody produced in mouse has been used in:

antibody microarray
western blotting
enzyme linked immunosorbent assay (ELISA)`
immunoprecipitation
immunocytochemistry

Biochem/physiol Actions

Heterogeneous nuclear ribonucleoproteins C1/C2(HnRNP C1/C2) is involved in protein translation, mRNA biogenesis and transport. The hnRNP-C proteins preferentially bind to uridine-rich RNA sequences. Oligomerization of the protein through leucine rich regions in its C-terminal end is important for RNA binding. Mutation of the hnRNPC gene is implicated in embryonic lethal phenotype.

Physical form

Solution in phosphate buffered saline, pH 7.4, and 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	SAB2101056	R6278	R5653
Sigma-Aldrich R5028 Monoclonal Anti-hnRNP-C1/C2 antibody produced in mouse	Sigma-Aldrich SAB2101056 Anti-HNRNPC antibody produced in rabbit	Sigma-Aldrich R6278 Anti-hnRNP-U antibody, Mouse monoclonal	Sigma-Aldrich R5653 Monoclonal Anti-hnRNP-Q antibody produced in mouse
description clone 4F4, purified immunoglobulin, buffered aqueous solution	description affinity isolated antibody	description clone 3G6, purified from hybridoma cell culture	description clone 18E4, purified immunoglobulin, buffered aqueous solution
Gene Information human ... HNRNPC(3183)	Gene Information human ... HNRNPC(3183)	Gene Information human ... HNRNPU(3192)	Gene Information human ... SYNCRIP(10492)
species reactivity monkey, human, chicken, hamster	species reactivity horse, rabbit, guinea pig, rat, dog, human, bovine, goat	species reactivity human, monkey	species reactivity mouse, bovine, human, rat, canine, Xenopus, chicken
clone 4F4, monoclonal	clone polyclonal	clone 3G6, monoclonal	clone 18E4, monoclonal
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form purified immunoglobulin	antibody form affinity isolated antibody	antibody form purified from hybridoma cell culture	antibody form purified immunoglobulin
biological source mouse	biological source rabbit	biological source mouse	biological source mouse

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Storage Class

12 - Non Combustible Liquids

WGK

nwg

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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