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Anti-Rab8 antibody produced in rabbit

Name: Anti-Rab8 antibody produced in rabbit
Brand: SIGMA
Price: 606 USD
Availability: InStock

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

Anti-Mel transforming oncogene (RAB8 homolog), Anti-Mel transforming oncogene (derived from cell line NK14), Anti-RAB8 homolog, Anti-RAB8A, Anti-Ras-associated protein RAB8

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Size/SKU	Availability	Price
200 μL	Check Cart for Availability	$606.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD01634074

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IF, WB

Citations:

$606.00

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Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~24 kDa

species reactivity

mouse, human, rat

technique(s)

indirect immunofluorescence: 1:100-1:200 using mouse 3T3 and rat NRK cells, western blot: 1:250-1:500 using whole extract of human Jurkat cells

UniProt accession no.

P61006

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... RAB8A(4218)
mouse ... Rab8a(17274)
rat ... Rab8a(117103)

Description

General description

Rab proteins contain conserved regions involved in guanine-nucleotide binding and hypervariable COOH-terminal domains with a cysteine motif. Rab8 localizes to the trans-Golgi network (TGN), recycling endosomes, tubular structures in the cytosol, membrane protrusions and plasma membrane.

Application

Anti-Rab8 antibody produced in rabbit has been used in immunoblotting and immunofluorescence staining.

Biochem/physiol Actions

Activation of a Rab protein is coupled to its association with intracellular membranes, allowing it to recruit downstream effector proteins to the cytoplasmic surface of a subcellular compartment. Through their effector proteins, Rab guanosine triphosphate (GTPases) regulate vesicle formation, actin- and tubulin-dependent vesicle movement and membrane fusion. The guanine-nucleotide binding and hypervariable COOH-terminal domains are implicated in subcellular targeting. Each Rab shows a characteristic subcellular distribution. Therefore, antibodies to Rab proteins may serve as useful tools for studying subcellular localization and membrane organization.

Rab8 (Ras-related protein Rab-8A) controls polarized trafficking, that helps in the formation of protrusion, ciliogenesis or intestinal epithelial. It may involve in the malignant development of EC (endometrial cancer). In human, Rab8 also participates in the dengue virus infection. It controls the translocation of in muscle cells.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	WH0004218M2	ABT165	HPA044575
$Anti-Rab8 antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich R5530 Anti-Rab8 antibody produced in rabbit	Sigma-Aldrich WH0004218M2 Monoclonal Anti-RAB8A antibody produced in mouse	Sigma-Aldrich ABT165 Anti-RAB8A Antibody	Sigma-Aldrich HPA044575 Anti-RAB28 antibody produced in rabbit
description IgG fraction of antiserum, buffered aqueous solution	description clone 3G1, purified immunoglobulin, buffered aqueous solution	description from rabbit, purified by affinity chromatography	description Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
antibody form IgG fraction of antiserum	antibody form purified immunoglobulin	antibody form affinity isolated antibody	antibody form affinity isolated antibody
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 100
biological source rabbit	biological source mouse	biological source rabbit	biological source rabbit
form buffered aqueous solution	form buffered aqueous solution	form -	form buffered aqueous glycerol solution
shipped in dry ice	shipped in dry ice	shipped in wet ice	shipped in wet ice

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Storage Class

10 - Combustible liquids

WGK

WGK 2

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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