R6152
Ranolazine dihydrochloride
≥98% (HPLC), powder, Na⁺-current blocker
Sinónimos:
(±) -4-[2-Hydroxy-3-(o-methoxyphenoxy)propyl]-1-piperazineaceto-2′,6′-xylidide dihydrochloride, N-(2,6-Dimethylphenyl)-4-[2-hydroxy-3-(2-methoxyphenoxy)propyl]-1-piperazineacetamide dihydrochloride
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| Talla/SKU | Disponibilidad | Precio |
|---|---|---|
100 mg | Envío estimado HOYdesdeMILWAUKEE | $296.00 |
500 mg | Envío estimado HOYdesdeMILWAUKEE | $1,010.00 |
Acerca de este artículo
$296.00
Envío estimado HOYDetalles
Nombre del producto
Ranolazine dihydrochloride, ≥98% (HPLC), powder
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to beige
mp
222-229.5 °C (lit.)
solubility
H2O: soluble ≥10 mg/mL
originator
Gilead
SMILES string
Cl.Cl.COc1ccccc1OCC(O)CN2CCN(CC2)CC(=O)Nc3c(C)cccc3C
InChI
1S/C24H33N3O4.2ClH/c1-18-7-6-8-19(2)24(18)25-23(29)16-27-13-11-26(12-14-27)15-20(28)17-31-22-10-5-4-9-21(22)30-3;;/h4-10,20,28H,11-17H2,1-3H3,(H,25,29);2*1H
InChI key
RJNSNFZXAZXOFX-UHFFFAOYSA-N
Gene Information
human ... SCN4A(6329), SCN5A(6331)
Application
- as a low Torsades-de-pointes (TdP) risk drug to study its effects on QTc prolongation, electrocardiographic (PR and QRS) intervals in dog cardiovascular model
- as a partial fatty acid oxidation (FAO) inhibitor to study its effects on glioblastoma cells
- as a late sodium(Na+)-current (INaL) inhibitor to study its effects on atrial tachycardia in rabbit heart
Biochem/physiol Actions
Features and Benefits
1 of 1
Este artículo | |||
|---|---|---|---|
| description ≥98% (HPLC), powder | description ≥98% (HPLC) | description ≥98% (HPLC), solid | description ≥98% (HPLC) |
| form powder | form powder | form solid | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| solubility H2O: soluble ≥10 mg/mL | solubility DMSO: 5 mg/mL, clear (warmed) | solubility H2O: soluble | solubility DMSO: >20 mg/mL |
| storage condition desiccated | storage condition desiccated | storage condition desiccated | storage condition desiccated |
| color white to beige | color white to beige | color off-white to light tan | color off-white |
Clase de almacenamiento
11 - Combustible Solids
¿Qué está pasando?
WGK 3
Punto de inflamación (°F)
Not applicable
Punto de inflamación (°C)
Not applicable
EPI (equipos de protección individual)
Eyeshields, Gloves, type N95 (US)
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