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Anti-phospho-Retinoblastoma (pSer^807,811) antibody produced in rabbit

Name: Anti-phospho-Retinoblastoma (pSer<SUP>807,811</SUP>) antibody produced in rabbit
Brand: SIGMA
Price: 855 USD
Availability: InStock

affinity isolated antibody, buffered aqueous glycerol solution

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0.1 mL	Check Cart for Availability	$855.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD02097167

Conjugate:

unconjugated

Clone:

polyclonal

Application:

WB CL

Citations:

$855.00

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Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous glycerol solution

species reactivity

rat, mouse, human

technique(s)

western blot (chemiluminescent): 1:1,000 using human fibroblasts synchronized by serum deprivation

UniProt accession no.

P06400

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer807/pSer811)

Gene Information

human ... RB1(5925)
mouse ... Rb1(19645)
rat ... Rb1(24708)

Description

General description

RB1 (RB transcriptional corepressor 1) codes for nuclear phosphoprotein pRB (retinoblastoma protein). It is located on human chromosome 13q14. It is a tumor-suppressor gene.

Immunogen

synthetic peptide corresponding to residues around phosphoserine 807/811 of the human retinoblastoma tumor suppressor protein (Rb), conjugated to KLH.

Application

Anti-phospho-Retinoblastoma (pSer807,811) has been used in western blotting.

Biochem/physiol Actions

RB1 (RB transcriptional corepressor 1) plays an important role throughout G1/S phase transition. Absence of RB induces prostate cancer metastasis. It plays an important role in modulating the cell cycle. It also regulates cell stemness and differentiation.

Recognizes phosphorylated Rb (Ser⁸⁰⁷/Ser⁸¹¹) and does not react with non-phosphorylated Rb. Does not react with Rb phosphorylated at other sites.

Physical form

Solution in 10 mM sodium HEPES, pH 7.5, containing 150 mM sodium chloride, 100 μg/ml bovine serum albumin and 50% glycerol.

Preparation Note

Purified using protein A and peptide affinity chromatography.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	SAB4502589	SAB4504527	SAB4502584
Sigma-Aldrich R6400 Anti-phospho-Retinoblastoma (pSer^807,811) antibody produced in rabbit	Sigma-Aldrich SAB4502589 Anti-Retinoblastoma, C-Terminal antibody produced in rabbit	Sigma-Aldrich SAB4504527 Anti-phospho-Retinoblastoma (pSer⁸⁰⁷) antibody produced in rabbit	Sigma-Aldrich SAB4502584 Anti-Retinoblastoma, C-Terminal antibody produced in rabbit
description affinity isolated antibody, buffered aqueous glycerol solution	description affinity isolated antibody	description affinity isolated antibody	description affinity isolated antibody
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 100
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
technique(s) western blot (chemiluminescent): 1:1,000 using human fibroblasts synchronized by serum deprivation	technique(s) ELISA: 1:20000, western blot: 1:500-1:1000, immunohistochemistry: 1:50-1:100	technique(s) ELISA: 1:10000, western blot: 1:500-1:1000, immunohistochemistry: 1:50-1:100	technique(s) immunofluorescence: 1:100-1:500, ELISA: 1:1000, immunohistochemistry: 1:50-1:100
UniProt accession no. P06400	UniProt accession no. P06400	UniProt accession no. P06400	UniProt accession no. P06400

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Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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