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R7532

RRD-251 hydrochloride

≥98% (HPLC)

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Synonym(s):

(2,4-Dichlorophenyl)carbamimidothioic acid methyl ester hydrochloride, 2-(2,4-Dichlorobenzyl)-2-thiopseudourea hydrochloride, Rb/Raf-1 disruptor 251 hydrochloride, S-(2,4-Dichlorobenzyl)-isothiouronium hydrochloride

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Size/SKUAvailabilityPrice
5 mg

Estimated to ship TODAYfromMILWAUKEE

$59.90

About This Item

Empirical Formula (Hill Notation):
C8H8Cl2N2S· HCl
CAS Number:
Molecular Weight:
271.59
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated

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Quality Segment

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to off-white

solubility

DMSO: >10 mg/mL, H2O: >2 mg/mL

storage temp.

room temp

SMILES string

Cl.NC(=N)SCc1ccc(Cl)cc1Cl

InChI

1S/C8H8Cl2N2S.ClH/c9-6-2-1-5(7(10)3-6)4-13-8(11)12;/h1-3H,4H2,(H3,11,12);1H

InChI key

COMNQRICZGJVLE-UHFFFAOYSA-N

Biochem/physiol Actions

RRD-251 hydrochloride is a reversible, potent, and selective disruptor of Rb/Raf-1 interaction.
RRD-251 hydrochloride is a reversible, potent, and selective disruptor of Rb/Raf-1 interaction. The retinoblastoma tumor suppressor protein (Rb) controls the G1-S boundary by repressing the transcriptional activity of the E2F family of transcription factors. Raf-1 kinase binds and phosphorylates Rb early in the G1 phase. RRD-251 significantly inhibits angiogenesis and tumor growth in vivo in an Rb-dependent manner. RRD-251 does not inhibit the binding of B-Raf to Rb and Raf-1 to Mek1/2. Also, RRD-251 does not affect the kinase activities associated with cyclin D, cyclin E, or Raf-1.

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This Item
M2949SML0276PZ0250
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

storage condition

desiccated

storage condition

-

storage condition

desiccated

storage condition

-

solubility

DMSO: >10 mg/mL, H2O: >2 mg/mL

solubility

H2O: 15 mg/mL, clear

solubility

H2O: >15 mg/mL

solubility

H2O: 20 mg/mL, clear


Storage Class

11 - Combustible Solids

WGK

WGK 3



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