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R7532

RRD-251 hydrochloride

≥98% (HPLC)

Synonym(s):

(2,4-Dichlorophenyl)carbamimidothioic acid methyl ester hydrochloride, 2-(2,4-Dichlorobenzyl)-2-thiopseudourea hydrochloride, Rb/Raf-1 disruptor 251 hydrochloride, S-(2,4-Dichlorobenzyl)-isothiouronium hydrochloride

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Size/SKUAvailabilityPrice
5 mg

Estimated to ship TODAYfromMILWAUKEE

$62.10

About This Item

Empirical Formula (Hill Notation):
C8H8Cl2N2S· HCl
CAS Number:
Molecular Weight:
271.59
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated

$62.10


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Quality Segment

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to off-white

solubility

DMSO: >10 mg/mL, H2O: >2 mg/mL

storage temp.

room temp

SMILES string

Cl.NC(=N)SCc1ccc(Cl)cc1Cl

InChI

1S/C8H8Cl2N2S.ClH/c9-6-2-1-5(7(10)3-6)4-13-8(11)12;/h1-3H,4H2,(H3,11,12);1H

InChI key

COMNQRICZGJVLE-UHFFFAOYSA-N

Biochem/physiol Actions

RRD-251 hydrochloride is a reversible, potent, and selective disruptor of Rb/Raf-1 interaction.
RRD-251 hydrochloride is a reversible, potent, and selective disruptor of Rb/Raf-1 interaction. The retinoblastoma tumor suppressor protein (Rb) controls the G1-S boundary by repressing the transcriptional activity of the E2F family of transcription factors. Raf-1 kinase binds and phosphorylates Rb early in the G1 phase. RRD-251 significantly inhibits angiogenesis and tumor growth in vivo in an Rb-dependent manner. RRD-251 does not inhibit the binding of B-Raf to Rb and Raf-1 to Mek1/2. Also, RRD-251 does not affect the kinase activities associated with cyclin D, cyclin E, or Raf-1.

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This Item
475958SAB4502574
description

≥98% (HPLC)

description

The c-Raf Inhibitor controls the biological activity of c-Raf. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

description

affinity isolated antibody

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

-

form

powder

form

solid

form

buffered aqueous solution

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

room temp

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: >10 mg/mL, H2O: >2 mg/mL

solubility

DMSO: 10 mg/mL

solubility

-

storage condition

desiccated

storage condition

OK to freeze

storage condition

-


Storage Class

11 - Combustible Solids

WGK

WGK 3



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