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R8279

RG108

≥98% (HPLC), DNA methyltransferase (DMNT) inhibitor, powder

Synonym(s):

N-Phthalyl-L-tryptophan

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Size/SKUAvailabilityPrice
10 mg

Available to ship TODAYfromMILWAUKEE

$325.00

About This Item

Empirical Formula (Hill Notation):
C19H14N2O4
CAS Number:
Molecular Weight:
334.33
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$325.00


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Product Name

RG108, ≥98% (HPLC), powder

Quality Segment

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -250 to -310°, c = 0.5 in methanol

color

yellow

solubility

DMSO: >10 mg/mL

storage temp.

−20°C

SMILES string

OC(=O)[C@H](Cc1c[nH]c2ccccc12)N3C(=O)C4=CCCC=C4C3=O

InChI

1S/C19H16N2O4/c22-17-13-6-1-2-7-14(13)18(23)21(17)16(19(24)25)9-11-10-20-15-8-4-3-5-12(11)15/h3-8,10,16,20H,1-2,9H2,(H,24,25)/t16-/m0/s1

InChI key

LMAZUAXDZRILNJ-INIZCTEOSA-N

General description

RG108, a non-nucleoside analog is also called [2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl) propanoic acid.

Application

RG108 has been used:
  • in reprogramming and increasing cell plasticity of primary multipotent mesenchymal stromal cells (MMSC)
  • as an inhibitor of DNA methyltransferase (DNMTi) in human retinal pigment epithelial ARPE-19 cells
  • as a DNA methyltransferase inhibitor in C33A2 cells to test its effect on papillomavirus late gene expression (HPV16)

Biochem/physiol Actions

RG108 is less cytotoxic compared to azacytidine (5-Aza-dCR). It mediates radiosensitivity in esophageal cancer cells (EC). RG108 is a potent epigenetic modulator and a demethylating agent. It elicits non-cytotoxic functionality and may be useful in stem cell therapies based on human bone marrow-derived mesenchymal stem cells (hBMSCs). It interacts with DNA methyltransferase 1 at the catalytic domain region.
RG108 is a DNA methyltransferase (DMNT) inhibitor.
RG108 is a DNA methyltransferase (DMNT) inhibitor. It reactivates tumor suppressor gene expression (p16, SFRP1, secreted frizzled related protein-1, and TIMP-3) in tumor cells by DNA demethylation. RG108 also inhibits human tumor cell line (HCT116, NALM-6) proliferation and increased doubling time in culture.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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This Item
26092093690
description

≥98% (HPLC), powder

description

The DNA Methyltransferase Inhibitor, also referenced under CAS 32675-71-1, controls the biological activity of DNA Methyltransferase. This small molecule/inhibitor is primarily used for Cell Structure applications.

description

≥99.0% (AT)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥99.0% (AT)

form

powder

form

solid

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

-

solubility

DMSO: >10 mg/mL

solubility

methanol: soluble, DMSO: 100 mg/mL

solubility

-

color

yellow

color

yellow

color

-


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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