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R8526

RO-52 (SSA) human

recombinant, expressed in E. coli, liquid

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Synonym(s):

Anti-RO-52 antibody

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Size/SKUAvailabilityPrice
100 μg
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$509.00

About This Item

UNSPSC Code:
12352202
NACRES:
NA.56
MDL number:
MFCD03458409
Form:
liquid
Biological source:
human
Recombinant:
expressed in E. coli
Mol wt:
52 kDa by SDS-PAGE

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biological source

human

Quality Segment

200

recombinant

expressed in E. coli

form

liquid

mol wt

52 kDa by SDS-PAGE

technique(s)

ELISA: suitable

UniProt accession no.

P19474

storage temp.

−70°C

Gene Information

human ... TRIM21(6737)

General description

Research area: Cell Signaling
RO-52 (SSA), also called as tripartite motif-containing protein 21 (TRIM21) is a 52 kDa, ubiquitin E3 ligase. It has a N-terminal RING finger domain (Really Interesting New Gene), crucial for ubiquitination functionality. RO-52 (SSA) gene is mapped to human chromosome 11p5.5.

Application

RO-52 (SSA) human has been used:
  • as a component of the autoantigen array
  • to immobilise protein on the self-assembly monolayer
  • in enzyme-linked immunosorbent assays (ELISAs)

Biochem/physiol Actions

RO-52 (SSA) is capable of autoubiquitination and uniquitylates p62 protein and regulates redox homeostasis.Patients with Sjogren′s syndrome display elevated levels of anti-Ro/SSA antibodies. RO-52 levels in peripheral blood mononuclear cells (PBMC) contributes to pathogenesis of systemic lupus erythematosus (SLE), systemic autoimmune rheumatic diseases (SARDs), interstitial lung disease (ILD) and connective tissue diseases (CTD). RO-52 is considered as potential target for treating SLE.
Used for the detection and quantification of antibodies to RNPs in rheumatic diseases.

Physical form

solution contains 20 mM phosphate buffer, 500 mM NaCl, 2M - 3M urea, pH 6.

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RO-52 (SSA) human recombinant, expressed in E. coli, liquid

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Sigma-Aldrich

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Anti-RNF125 antibody produced in rabbit

description

recombinant, expressed in E. coli, liquid

description

>90% (SDS-PAGE), recombinant, expressed in E. coli (N-terminal histidine tagged), buffered aqueous solution

description

recombinant, expressed in E. coli, His tagged, >90% (SDS-PAGE)

description

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

biological source

human

biological source

-

biological source

human

biological source

rabbit

recombinant

expressed in E. coli

recombinant

expressed in E. coli (N-terminal histidine tagged)

recombinant

expressed in E. coli

recombinant

-

technique(s)

ELISA: suitable

technique(s)

-

technique(s)

-

technique(s)

immunohistochemistry: 1:200- 1:500

mol wt

52 kDa by SDS-PAGE

mol wt

~100 kDa by SDS-PAGE

mol wt

~25 kDa by SDS-PAGE

mol wt

-

form

liquid

form

buffered aqueous solution

form

lyophilized

form

buffered aqueous glycerol solution

storage temp.

−70°C

storage temp.

−70°C

storage temp.

−20°C

storage temp.

−20°C

Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000496789
    0000420561
    0000444365
    0000420568
    0000313881

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