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R8781

Rapamycin

from Streptomyces hygroscopicus, ≥95% (HPLC), solution, mTOR inhibitor

Synonym(s):

23,27-Epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclohentriacontine solution

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Size/SKUAvailabilityPrice
200 μL

Available to ship TODAYfromMILWAUKEE

$335.00

About This Item

Empirical Formula (Hill Notation):
C51H79NO13
Molecular Weight:
914.17
UNSPSC Code:
12352200
EC Number:
200-664-3
NACRES:
NA.77
Assay:
≥95% (HPLC)
Form:
solution

$335.00

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Product Name

Rapamycin, Ready Made Solution, 2.5 mg/mL in DMSO (2.74 mM), from Streptomyces hygroscopicus

biological source

Streptomyces hygroscopicus

Quality Segment

vapor pressure

0.56 hPa ( 20 °C)

assay

≥95% (HPLC)

form

solution

autoignition temp.

301 °C

concentration

2.5 mg/mL in DMSO (2.74 mM)

color

colorless to yellow

antibiotic activity spectrum

fungi, yeast

mode of action

enzyme | inhibits

storage temp.

−20°C

General description

Rapamycin is a macrocyclic triene antibiotic possessing potent immunosuppressant and anticancer activity. It forms a complex with FKBP12 that binds to and inhibits the molecular target of rapamycin (mTOR). mTOR is a member of the phosphoinositide kinase-related kinase (PIKK) family that enhances cellular proliferation via the phosphoinositol 3-kinase/Akt signaling pathway. Inhibition of this pathway by rapamycin blocks downstream elements that result in cell cycle arrest in G1. The effectors of mTOR action include 4EBP1 and S6K1.
Rapamycin, an mTOR inhibitor, is derived from Streptomyces hygroscopicus. It can inhibit viral replication. This natural anti-fungal antibiotic is a proven anti-aging agent. Rapamycin significantly inhibits mTORC1 regardless of age.

Application

Rapamycin has been used:
  • as a supplement in mTeSR1 medium to culture induced pluripotent stem cell (iPSC) colonies for induction of autophagy signaling
  • to treat the Drosophila S2 cells at 65-70% confluence,
  • to measure protein synthesis
  • to stimulate autophagy in ovarian cancer cells

Packaging

200uL

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research
Keep container tightly closed in a dry and well-ventilated place. Store under inert gas. Is Hygroscopic.
Rapamycin has been expertly reviewed and recommended by the Chemical Probes Portal. For more information, please visit the Rapamycin probe summary on the Chemical Probes Portal website.

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This Item
R0395S4068U1128
Rapamycin Ready Made Solution, 2.5 mg/mL in DMSO (2.74 mM), from Streptomyces hygroscopicus

Sigma-Aldrich

R8781

Rapamycin

Rapamycin from Streptomyces hygroscopicus ≥95% (HPLC), powder

Sigma-Aldrich

R0395

Rapamycin from Streptomyces hygroscopicus

Splitomicin ≥98% (HPLC), powder

Sigma-Aldrich

S4068

Splitomicin

Uracil BioReagent, suitable for cell culture

Sigma-Aldrich

U1128

Uracil

description

Ready Made Solution, 2.5 mg/mL in DMSO (2.74 mM), from Streptomyces hygroscopicus

description

≥95% (HPLC), powder

description

≥98% (HPLC), powder

description

BioReagent, suitable for cell culture

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

≥99% (HPLC)

form

solution

form

powder

form

powder

form

powder

Quality Level

300

Quality Level

300

Quality Level

100

Quality Level

200

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

room temp

color

colorless to yellow

color

off-white

color

-

color

-

concentration

2.5 mg/mL in DMSO (2.74 mM)

concentration

-

concentration

-

concentration

-

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Storage Class

10 - Combustible liquids

WGK

WGK 1

Flash Point (°F)

188.6 °F - closed cup

Flash Point (°C)

87 °C - closed cup

PPE (personal protective equipment)

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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