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S0149

Streptolysin O from Streptococcus pyogenes

From Streptococcus pyogenes, Thiol-activated toxin, lyophilized powder

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25000 units
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$311.00
$264.35

About This Item

CAS Number:
98072-47-0
UNSPSC Code:
12352200
NACRES:
NA.77
EC Number:
308-500-3
MDL number:
MFCD00132389
Form:
lyophilized powder

$264.35

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Product Name

Streptolysin O from Streptococcus pyogenes, γ-irradiated

biological source

Streptococcus pyogenes

Quality Segment

200

sterility

γ-irradiated

form

lyophilized powder

application(s)

cell analysis

storage temp.

2-8°C

Gene Information

Streptococcus pyogenes ... slo(900490)

Application

Permeabilizes membranes to permit cellular uptake of large or charged molecules.
Streptolysin O from Streptococcus pyogenes has been used in streptolysin O (SLO) permeabilization. It has also been used to evaluate the barrier integrity and cytotoxicity of caco-2 and T84 IEC polarized monolayers.

Biochem/physiol Actions

Thiol-activated toxin that permeabilizes animal cell membranes. The protein binds as a monomer to membrane cholesterol and subsequently polymerizes into large arc- and ring-shaped structures surrounding pores of >12 nm.
Thiol-activated toxin that permeabilizes animal cell membranes..
Streptolysin O (SLO), obtained from Streptococcus pyogenes has the capability to block osteoclastogenesis, induced by receptor activator of nuclear factor κ-Β ligand (RANK) through the NF-κB signaling pathway. Streptococcus pyogenes (GAS) is a bacterial strain that results in bacterial arthritis, osteomyelitis and implant infections.

Preparation Note

Prepared from S 5265

Other Notes

One unit will cause 50% lysis of 2% red blood cell suspensions in phosphate buffered saline, pH 7.4, after incubation at 37 °C for 30 min.

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This Item
S5265SAE0089D0564
Streptolysin O from Streptococcus pyogenes γ-irradiated

Sigma-Aldrich

S0149

Streptolysin O from Streptococcus pyogenes

Streptolysin O from Streptococcus pyogenes lyophilized powder, Protein ~3 % by Lowry, 25,000-50,000 U/vial

Sigma-Aldrich

S5265

Streptolysin O from Streptococcus pyogenes

Streptolysin O from Streptococcus pyogenes ≥1,000,000 units/mg protein, recombinant, lyophilized powder, expressed in E. coli

Sigma-Aldrich

SAE0089

Streptolysin O from Streptococcus pyogenes

Diphtheria Toxin from Corynebacterium diphtheriae lyophilized powder, Product is in unnicked form

Sigma-Aldrich

D0564

Diphtheria Toxin from Corynebacterium diphtheriae

description

γ-irradiated

description

lyophilized powder, Protein ~3 % by Lowry, 25,000-50,000 U/vial

description

≥1,000,000 units/mg protein, recombinant, lyophilized powder, expressed in E. coli

description

lyophilized powder, Product is in unnicked form

form

lyophilized powder

form

lyophilized powder

form

-

form

lyophilized powder

Quality Level

200

Quality Level

200

Quality Level

-

Quality Level

200

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

sterility

γ-irradiated

sterility

-

sterility

-

sterility

-

biological source

Streptococcus pyogenes

biological source

-

biological source

-

biological source

-

application(s)

cell analysis

application(s)

-

application(s)

-

application(s)

-

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pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 1 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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