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S0278

(±)-Sotalol hydrochloride

≥98% (TLC), powder, β-Adrenoceptor antagonist

Synonym(s):

N-[4-[1-Hydroxy-2-(isopropylamino)ethyl]phenyl]methanesulfonamide hydrochloride

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Size/SKUAvailabilityPrice
25 mg
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$124.00
100 mg
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$401.00

About This Item

Empirical Formula (Hill Notation):
C12H20N2O3S · HCl
CAS Number:
959-24-0
Molecular Weight:
308.82
NACRES:
NA.77
PubChem Substance ID:
24278689
UNSPSC Code:
12352200
EC Number:
213-496-0
MDL number:
MFCD00242937
Assay:
≥98% (TLC)
Form:
powder

$124.00

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Product Name

(±)-Sotalol hydrochloride, ≥98% (TLC), powder

Quality Segment

assay

≥98% (TLC)

form

powder

color

white to off-white

solubility

H2O: 20 mg/mL

originator

Bayer

SMILES string

Cl.CC(C)NCC(O)c1ccc(NS(C)(=O)=O)cc1

InChI

1S/C12H20N2O3S.ClH/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17;/h4-7,9,12-15H,8H2,1-3H3;1H

InChI key

VIDRYROWYFWGSY-UHFFFAOYSA-N

Gene Information

Application

(±)-Sotalol hydrochloride has been used to test its effect on the cardiac action potential (AP) in human hearts. It has also been used as an β- blocker to determine its effect on free intracellular calcium (Ca2+) release and whole-cell currents in mammalian cancer cells.

Biochem/physiol Actions

Potent β-adrenoceptor antagonist; class III antiarrhythmic; prolongs the action potential and increases the refractory period.
Sotalol has a potential to block non-cardioselective β-adrenergic receptors. It acts as an anti-arrhythmic agent and is used as a therapeutic for equine arrhythmias. In addition, sotalol also has an ability to stop atrial fibrillation recurrence.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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This Item
PHR2798BP4981617408
(±)-Sotalol hydrochloride ≥98% (TLC), powder

Sigma-Aldrich

S0278

(±)-Sotalol hydrochloride

Sotalol Hydrochloride

Supelco

PHR2798

Sotalol Hydrochloride

Sotalol hydrochloride British Pharmacopoeia (BP) Reference Standard

BP498

Sotalol hydrochloride

Sotalol hydrochloride United States Pharmacopeia (USP) Reference Standard

USP

1617408

Sotalol hydrochloride

description

≥98% (TLC), powder

description

-

description

British Pharmacopoeia (BP) Reference Standard

description

United States Pharmacopeia (USP) Reference Standard

form

powder

form

-

form

crystalline

form

-

assay

≥98% (TLC)

assay

-

assay

-

assay

-

Quality Level

200

Quality Level

300

Quality Level

-

Quality Level

-

solubility

H2O: 20 mg/mL

solubility

-

solubility

-

solubility

-

originator

Bayer

originator

-

originator

-

originator

-

color

white to off-white

color

-

color

-

color

-

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

dust mask type N95 (US), Eyeshields, Gloves

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