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Monoclonal Anti-Syntaxin antibody produced in mouse

Name: Monoclonal Anti-Syntaxin antibody produced in mouse
Brand: SIGMA
Price: 533 USD
Availability: InStock

clone HPC-1, ascites fluid

Synonym(s):

Anti-HPC-1, Anti-P35-1, Anti-STX1, Anti-SYN1A

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Size/SKU	Availability	Price
100 μL	Available to ship TODAYfromMILWAUKEE	$533.00
0.2 mL	Available to ship TODAYfromMILWAUKEE	$727.00 $617.95

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD00164742

Conjugate:

unconjugated

Clone:

HPC-1, monoclonal

Application:

ARR, ICC, WB

Citations:

133

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Properties

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

HPC-1, monoclonal

mol wt

antigen 35 kDa

contains

15 mM sodium azide

species reactivity

rat, bovine, rabbit

technique(s)

immunocytochemistry: suitable using monolayer cultures of neonatal retina cells, microarray: suitable, western blot: 1:2,000 using crude preparation of synaptic vesicles from rat cerebral cortex

isotype

IgG1

UniProt accession no.

P32850

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

rat ... Stx1a(116470)

Description

General description

Monoclonal Anti-Syntaxin (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Syntaxin (also cited as HPC-1 antigen), a 35 kDa molecule with carboxyl-terminal membrane anchor is a synaptic protein. Syntaxin 1 is a membrane protein. Neurons express syntaxin 1A.

Syntaxin is a 35kD synaptic protein capable of interacting with the synaptic vesicle protein synaptotagmin. It facilitates the docking and fusion of synaptic vesicles with the plasma membrane. Monoclonal anti-syntaxin antibody can be used to screen λ gt 11 library of rat hippocampus to isolate syntaxin cDNA clones. It can also be used in microarray and immunocytochemistry. Mouse anti-syntaxin antibody reacts specifically with membrane protein syntaxin (35 kD). The product has also shown cross reactivity for rabbit, rat and bovine but not for guinea pig.

Immunogen

synaptosomal plasma-membrane fraction from adult rat hippocampus.

Application

Monoclonal Anti-Syntaxin antibody produced in mouse has been used in:

immunoblotting
immunohistochemistry
immunoprecipitation from hippocampal lysate
immunohistochemical analysis

Monoclonal anti-syntaxin antibody can be used in immunoprecipitation and immunohistochemistry. It can also be used in western blotting. Further, this product can also be used to label monolayer cultures of neonatal retinal cells and frozen paraformaldehyde fixed tissue sections.

Biochem/physiol Actions

Syntaxin 1 (STX1A) may control exocytosis in synaptic vesicles. In retina, STX1A may help in the structural formation of the inner nuclear layer (INL) and outer plexiform layer (OPL). Deletion of STX1A in mice affects the functions of hypothalamic-pituitary-adrenal axis. It may participate in spinal nociceptive plasticity promoted by peripheral nerve injury. It has been implicated in docking at synaptic vesicles of presynaptic neurotransmitter release sites.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	SAB4200841	C7082	T2928
Sigma-Aldrich S0664 Monoclonal Anti-Syntaxin antibody produced in mouse	Sigma-Aldrich SAB4200841 Anti-Syntaxin antibody, Mouse monoclonal	Sigma-Aldrich C7082 Monoclonal Anti-β-Catenin antibody produced in mouse	Sigma-Aldrich T2928 Anti-Tyrosine Hydroxylase antibody Mouse Monoclonal Antibody
description clone HPC-1, ascites fluid	description clone HPC-1, purified from hybridoma cell culture	description clone 6F9, ascites fluid	description clone TH-16, purified from hybridoma cell culture
species reactivity rat, bovine, rabbit	species reactivity monkey, rat, human, dog, mouse, bovine	species reactivity human, chicken, canine, bovine	species reactivity rat, sheep, human, monkey, bovine, rabbit, guinea pig
conjugate unconjugated	conjugate -	conjugate unconjugated	conjugate unconjugated
Gene Information rat ... Stx1a(116470)	Gene Information -	Gene Information human ... CTNNB1(1499)	Gene Information human ... TH(7054) rat ... Th(25085)
clone HPC-1, monoclonal	clone HPC-1, monoclonal	clone 6F9, monoclonal	clone TH-16
biological source mouse	biological source -	biological source mouse	biological source mouse
antibody form ascites fluid	antibody form purified from hybridoma cell culture	antibody form ascites fluid	antibody form purified from hybridoma cell culture

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Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c