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S2075

Src Inhibitor-1

≥98% (HPLC), Src kinase inhibitor, powder

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Synonym(s):

4-(4′-Phenoxyanilino)-6,7-dimethoxyquinazoline, 6,7-Dimethoxy-N-(4-phenoxyphenyl)-4-quinazolinamine, SKI-1, Src-l1

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Size/SKUAvailabilityPrice
5 mg
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$201.00

About This Item

Empirical Formula (Hill Notation):
C22H19N3O3
CAS Number:
179248-59-0
Molecular Weight:
373.40
UNSPSC Code:
12352200
PubChem Substance ID:
329824504
NACRES:
NA.77
MDL number:
MFCD01815300
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated

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Product Name

Src Inhibitor-1, ≥98% (HPLC)

Quality Segment

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

SMILES string

COc1cc2ncnc(Nc3ccc(Oc4ccccc4)cc3)c2cc1OC

InChI

1S/C22H19N3O3/c1-26-20-12-18-19(13-21(20)27-2)23-14-24-22(18)25-15-8-10-17(11-9-15)28-16-6-4-3-5-7-16/h3-14H,1-2H3,(H,23,24,25)

InChI key

DMWVGXGXHPOEPT-UHFFFAOYSA-N

Application

Src Inhibitor-1 may be used in Src kinase-mediated cell signaling studies.

Biochem/physiol Actions

Apart from Src kinase, some Src inhibitors also inhibit the activity of Abl kinase, Lck, Csk and Yes proteins and are therefore being explored as viable anti-cancer drug options.
Src Inhibitor-1 is a potent, competitve dual site (both the ATP- and peptide-binding) Src kinase inhibitor.
Src Inhibitor-1 is a potent, competitve dual site (both the ATP- and peptide-binding) Src kinase inhibitor. Src Inhibitor-1 is one of the "gold standards" for Src kinase inhibition. It has been shown to use PP1 or PP2 in parallel with Src-I1 to inhbit Src family kinases. Src Inhibitor-1 is a selective, competitive inhibitor of Src family of tyrosine kinases (IC50 = 44 nM and 88 nM for Src and Lck, respectively). Src Inhibitor-1 Inhibits VEGFR2 and c-fms tyrosine kinases at much higher concentrations (IC50 = 0.32 μM and 30 μM, respectively).

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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1 of 1

This Item
539571518654ALD00528
Src Inhibitor-1 ≥98% (HPLC)

Sigma-Aldrich

S2075

Src Inhibitor-1

Src Inhibitor, PP1 InSolution, ≥90%

Sigma-Aldrich

539571

Src Inhibitor, PP1

4-Amino-2-chloro-6,7-dimethoxyquinazoline 95%

Sigma-Aldrich

518654

4-Amino-2-chloro-6,7-dimethoxyquinazoline

Serine Hydrolase Inhibitor-1

Sigma-Aldrich

ALD00528

Serine Hydrolase Inhibitor-1

description

≥98% (HPLC)

description

InSolution, ≥90%

description

95%

description

-

assay

≥98% (HPLC)

assay

≥90% (HPLC)

assay

95%

assay

-

form

powder

form

liquid

form

-

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

-

storage temp.

-

solubility

DMSO: >10 mg/mL

solubility

-

solubility

-

solubility

-

storage condition

desiccated

storage condition

protect from light, OK to freeze, avoid repeated freeze/thaw cycles, desiccated (hygroscopic)

storage condition

-

storage condition

-

Storage Class

11 - Combustible Solids

WGK

WGK 3

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Certificates of Analysis (COA)

Lot/Batch Number
0000045668
0000505697
0000133718
0000059767
0000133717

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