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Anti-S-100 antibody produced in rabbit

Name: Anti-S-100 antibody produced in rabbit
Brand: SIGMA
Price: 598 USD
Availability: InStock

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

Anti-42C, Anti-ANX2LG, Anti-CAL1L, Anti-CLP11, Anti-Ca[1], Anti-GP11, Anti-P11, Anti-p10

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Size/SKU	Availability	Price
0.2 mL	Available to ship TODAYfromMILWAUKEE	$598.00
1 mL	Available to ship TODAYfromMILWAUKEE	$868.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD00145919

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ARR, IHC (p)

Citations:

$598.00

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Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

rat, bovine, guinea pig, human

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 20-100 μg/mL using sections of human or rat cerebellum, microarray: suitable

UniProt accession no.

P60903

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

rat ... S100a10(81778)

Description

General description

S-100 (S100 calcium binding protein A10) belongs to the EF-hand-containing S100 protein family. It is also termed as calpactin light chain, p11 or annexin 2 light chain. This gene is located on human chromosome 1q21.

S100 calcium binding protein A10 (S-100) is located on rat chromosome 2q34. It is also termed as p11.

The S-100 protein family consists of around 16 calcium binding proteins that have distinct tissue specific expression patterns. S-100 proteins are widely expressed in neural and non-neural cell types, as well as in several cancers. These proteins regulate a broad range of cellular functions such as cell growth, signaling, cell structure, and energy metabolism . In immunohistology, the product specifically stains the S-100 protein. The product binds to S-100 protein in human, rat, guinea pig, and bovine. In the brain, the antibody can be used to stain glial and ependymal cells, as well as Schwann cells of the peripheral nervous system. In the skin, melanocytes and Langerhans cells can be stained by the antibody product. In lymph nodes, interdigitating reticulum cells are positively stained by anti-S-100 antibody. S-100 staining can be observed in almost all human benign and malignant melanocytic tumors.

Immunogen

S-100 from bovine brain

Application

Anti-S-100 antibody is suitable for use in microarray, and immunohistochemistry (in formalin-fixed, paraffin-embedded sections, or using a conc. of 20-100 μg/mL in sections of human or rat cerebellum). The antibody may also be used in immunoelectrophoresis.

Anti-S-100 antibody has been used in immunocytochemistry,[25} immunofluorescence and immunostaining.

Biochem/physiol Actions

S-100 (S100 calcium binding protein A10) is required for trafficking of TRPV5 and TRPV6 (epithelial Ca²⁺ channels). S100A10 along with annexin 2, participates in several biological processes such as endocytosis, exocytosis and membrane-cytoskeleton interactions. It controls plasma membrane ion channels and cytosolic phospholipase A2.

S100 calcium binding protein A10 (S-100) plays an important role in depression-like character in rodents. In rat ventricular cardiomyocytes, p11 regulates calcium handling through 5-HT₄R pathway.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	S2657	S2532	S9684
$Anti-S-100 antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich S2644 Anti-S-100 antibody produced in rabbit	Sigma-Aldrich S2657 Anti-S-100 (β-Subunit) antibody, Mouse monoclonal	Sigma-Aldrich S2532 Monoclonal Anti-S-100 (β-Subunit) antibody produced in mouse	$Anti-SNAP-25 antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich S9684 Anti-SNAP-25 antibody produced in rabbit
description IgG fraction of antiserum, buffered aqueous solution	description clone SH-B4, purified from hybridoma cell culture	description clone SH-B1, ascites fluid	description IgG fraction of antiserum, buffered aqueous solution
antibody form IgG fraction of antiserum	antibody form (Solution in 0.01M phosphate buffered saline pH 7.4, containing 15mM sodium azide as a preservative)	antibody form ascites fluid	antibody form IgG fraction of antiserum
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
biological source rabbit	biological source mouse	biological source mouse	biological source rabbit
species reactivity rat, bovine, guinea pig, human	species reactivity sheep, bovine, goat, pig, feline, rabbit, rat, canine, human	species reactivity feline, pig, bovine, sheep, goat, rabbit, canine, human, rat	species reactivity rat, mouse
Gene Information rat ... S100a10(81778)	Gene Information human ... S100B(6285) rat ... S100b(25742)	Gene Information human ... S100B(6285) rat ... S100b(25742)	Gene Information human ... SNAP25(6616) mouse ... Snap25(20614) rat ... Snap25(25012)

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Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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