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SB-408124

Name: SB-408124
Brand: SIGMA
Price: 193.8 USD
Availability: InStock

≥98% (HPLC), solid

Synonym(s):

N-(6,8-Difluoro-2-methyl-4-quinolinyl)-N′-[4-(dimethylamino)phenyl]urea

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Size/SKU	Availability	Price
5 mg	Estimated to ship TODAYfromMILWAUKEE	$228.00 $193.80
25 mg	Estimated to ship TODAYfromMILWAUKEE	$623.00 $529.55

About This Item

Empirical Formula (Hill Notation):

C₁₉H₁₈F₂N₄O

CAS Number:

288150-92-5

Molecular Weight:

356.37

NACRES:

NA.77

PubChem Substance ID:

329824523

UNSPSC Code:

51111800

MDL number:

MFCD06411575

Assay:

≥98% (HPLC)

Form:

solid

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Properties

Quality Segment

100

assay

≥98% (HPLC)

form

solid

color

off-white

solubility

DMSO: >10 mg/mL

originator

GlaxoSmithKline

storage temp.

2-8°C

SMILES string

CN(C)c1ccc(NC(=O)Nc2cc(C)nc3c(F)cc(F)cc23)cc1

InChI

1S/C19H18F2N4O/c1-11-8-17(15-9-12(20)10-16(21)18(15)22-11)24-19(26)23-13-4-6-14(7-5-13)25(2)3/h4-10H,1-3H3,(H2,22,23,24,26)

InChI key

JTARFZSNUAGHRB-UHFFFAOYSA-N

Description

Application

SB-408124 was used to block orexin A-mediated cardiovascular effects in rats.It was used to study block the increase of endogenous glucose production mediated by bicuculline in rats.

Biochem/physiol Actions

SB-408124 blocks the orexin type 1 receptor that stimulates the production of stress hormone in hypothalamus. It blocks orexin A-induced increase in arterial pressure and elevation of heart rate in rats. SB-408124 modulates phrenic nerve activity that is important in respiration.

SB 408124 is an OX₁ orexin receptor antagonist.

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from GlaxoSmithKline

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Show Differences

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This Item	S0693	SML2281	F0430
Sigma-Aldrich S2694 SB-408124	Sigma-Aldrich S0693 SB 204741	Sigma-Aldrich SML2281 BAY 60-2770	Sigma-Aldrich F0430 Fenobam
description ≥98% (HPLC), solid	description >98% (HPLC)	description ≥98% (HPLC)	description ≥98% (HPLC), solid
form solid	form solid	form powder	form solid
assay ≥98% (HPLC)	assay >98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level -	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: >10 mg/mL	solubility DMSO: soluble >20 mg/mL	solubility DMSO: 2 mg/mL, clear	solubility DMSO: >20 mg/mL
originator GlaxoSmithKline	originator GlaxoSmithKline	originator -	originator Johnson & Johnson

Pictograms

GHS07

Signal Word

Warning

Hazard Codes

H315,H319,H335

Precautionary Statements

P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

dust mask type N95 (US), Eyeshields, Gloves

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