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Spermine tetrahydrochloride

Name: Spermine tetrahydrochloride
Brand: SIGMA
Price: 69.3 USD
Availability: InStock

powder or crystals, NMDA agonist/antagonist

Synonym(s):

N,N′-Bis(3-aminopropyl)-1,4-butanediamine tetrahydrochloride

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Size/SKU	Availability	Price
1 g	Available to ship TODAYfromMILWAUKEE	$69.30
5 g	Available to ship TODAYfromMILWAUKEE	$311.00
10 g	Estimated to ship onSeptember 24, 2026fromMILWAUKEE	$566.00
25 g	Estimated to ship onSeptember 24, 2026fromMILWAUKEE	$1,010.00 $858.50
100 g	Estimated to ship onSeptember 24, 2026fromMILWAUKEE	$3,270.00

About This Item

Empirical Formula (Hill Notation):

C₁₀H₂₆N₄ · 4HCl

CAS Number:

306-67-2

Molecular Weight:

348.18

NACRES:

NA.77

PubChem Substance ID:

24278007

UNSPSC Code:

12352200

EC Number:

206-189-8

MDL number:

MFCD00012914

Beilstein/REAXYS Number:

3911771

Form:

powder or crystals

$69.30

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Properties

Product Name

Spermine tetrahydrochloride, powder or crystals

form

powder or crystals

Quality Segment

200

mp

310-311 °C (dec.) (lit.)

solubility

water, high purity: 100 mg/ml

storage temp.

room temp

SMILES string

Cl.Cl.Cl.Cl.NCCCNCCCCNCCCN

InChI

1S/C10H26N4.4ClH/c11-5-3-9-13-7-1-2-8-14-10-4-6-12;;;;/h13-14H,1-12H2;4*1H

InChI key

XLDKUDAXZWHPFH-UHFFFAOYSA-N

Gene Information

human ... GRIN1(2902)

Description

Application

Spermine tetrahydrochloride was used to precipitate DNA for flow cytometric analysis from fresh frozen breast cancer tissue, archival tissue of salivary gland, renal and thyroid tumors and red blood cells of chicken.

Used to precipitate DNA from low salt aqueous buffers.

Biochem/physiol Actions

Spermine, a polyamine, is derived from spermidine and is required for cell growth in eukaryotes. It acts as regulator of gene expression, inhibits DNA damage and protects the cells from damage by acting as free radical scavenger. In proteomics studies, spermine mediates rapid crystallization of DNA-binding proteins.

Mixed NMDA agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Mixed NMDA agonist/antagonist at the polyamine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Mixed NMDA agonist/antagonist at the polyamine site. Role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

Preparation Note

Spermine tetrahydrochloride yields clear, colorless to light yellow solution in water at 100 mg/ml.

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This Item	85610	85605	85580
Sigma-Aldrich S2876 Spermine tetrahydrochloride	Sigma-Aldrich 85610 Spermine tetrahydrochloride	Sigma-Aldrich 85605 Spermine tetrahydrochloride	SAFC 85580 Spermidine trihydrochloride
description powder or crystals	description ≥99.0% (AT), powder or crystals	description BioUltra, Molecular Biology, ≥99.5% (AT)	description ≥99.0% (AT)
form powder or crystals	form powder or crystals	form powder	form powder
Quality Level 200	Quality Level 300	Quality Level 300	Quality Level 200
storage temp. room temp	storage temp. room temp	storage temp. -	storage temp. room temp
solubility water, high purity: 100 mg/ml	solubility H₂O: 0.1 g/mL, clear	solubility H₂O: 1 m at 20 °C, clear, colorless to almost colorless	solubility H₂O: 0.1 g/mL, clear, colorless
mp 310-311 °C (dec.) (lit.)	mp 310-311 °C (dec.) (lit.)	mp 310-311 °C (dec.) (lit.)	mp ~250 °C (dec.), 257-259 °C (lit.)
Gene Information human ... GRIN1(2902)	Gene Information -	Gene Information -	Gene Information -

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pictograms

GHS07

signalword

Warning

hcodes

H315,H319

pcodes

P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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