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Anti-α-Synuclein (SNCA) Antibody

Name: Anti-α-Synuclein (SNCA) Antibody
Brand: SIGMA
Price: 601 USD
Availability: InStock

rabbit polyclonal

Synonym(s):

Anti-SNCA

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Size/SKU	Availability	Price
0.2 mL	Available to ship TODAYfromMILWAUKEE	$601.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD02095740

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ARR, IHC (p), WB

Citations:

$601.00

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Properties

Product Name

Anti-α-Synuclein antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 19 kDa

species reactivity

rat, human

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:200 using formic acid treated sections of Alzheimer′s Disease brain, microarray: suitable, western blot: 1:1,000 using extract of rat brain homogenate

UniProt accession no.

P37840

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SNCA(6622)
rat ... Snca(29219)

Description

General description

The synucleins are a family of soluble presynaptic proteins that are abundant in neurons and include α-synuclein, β-synuclein, and γ-synuclein. Human α-synuclein (also known as the non-amyloid component of plaques precursor protein or NACP) is a 140-amino acid polypeptide that is encoded by a gene on chromosome 4. It was originally isolated from plaques of Alzheimer′s disease (AD) brains as a 19 kDa protein precursor of the highly hydrophobic 35-amino acid peptide, nonamyloid component (NAC) of plaques. The NAC can self-aggregate into fibrils and induce aggregation of the β-amyloid peptide. α-Synuclein is highly abundant in presynaptic terminals, and is a major component of Lewy bodies (LBs). Pathogenic point mutations in the α-synuclein gene are linked to familial Parkinson′s disease (PD) in rare kindreds. However, most neurodegenerative disorders with LBs are associated with abnormal accumulation of wild-type, α-synuclein. α-Synuclein is expressed primarily in brain, but is also expressed in low levels in all tissues examined except liver.

Immunogen

synthetic peptide corresponding to a sequence near the C-terminus of human α-synuclein (amino acids 111-132 with C-terminally added lysine) conjugated to KLH. This sequence is highly conserved (90% homology) in mouse and rat α-synuclein. This sequence has no homology with β- and γ-synuclein.

Application

Rabbit polyclonal anti-α-Synuclein antibody is used to tag α-Synuclein for detection and quantitation by immunocytochemical and immunohistochemical (IHC) techniques, such as immunoblotting. It is also used as a probe to determine the presence and roles of α-Synuclein in plaques of Alzheimer′s disease (AD) brains.

Biochem/physiol Actions

Rabbit polyclonal anti-α-Synuclein antibody recognizes human and rat α-synuclein. Staining of α-synuclein in immunoblotting is specifically inhibited by the immunizing peptide

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	S5566	SAB4502828	SAB4502829
$Anti-α-Synuclein antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich S3062 Anti-α-Synuclein antibody produced in rabbit	Sigma-Aldrich S5566 Anti-α-Synuclein antibody, Mouse monoclonal	Sigma-Aldrich SAB4502828 Anti-Synuclein antibody produced in rabbit	Sigma-Aldrich SAB4502829 Anti-Synuclein-α antibody produced in rabbit
description IgG fraction of antiserum, buffered aqueous solution	description clone Syn211, purified from hybridoma cell culture	description affinity isolated antibody	description affinity isolated antibody
Quality Level 200	Quality Level 200	Quality Level 100	Quality Level 100
antibody form IgG fraction of antiserum	antibody form purified immunoglobulin	antibody form affinity isolated antibody	antibody form affinity isolated antibody
biological source rabbit	biological source mouse	biological source rabbit	biological source rabbit
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
technique(s) western blot: 1:1,000 using extract of rat brain homogenate, immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:200 using formic acid treated sections of Alzheimer′s Disease brain, microarray: suitable	technique(s) western blot: 0.25 μg/mL using recombinant human α·-synuclein., immunoprecipitation (IP): suitable, immunohistochemistry: suitable	technique(s) immunohistochemistry: 1:50-1:100, western blot: 1:500-1:1000, ELISA: 1:1000	technique(s) ELISA: 1:40000, western blot: 1:500-1:1000
Gene Information human ... SNCA(6622) rat ... Snca(29219)	Gene Information human ... SNCA(6622)	Gene Information human ... SNCA(6622)	Gene Information human ... SNCA(6622)

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Storage Class

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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