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S3313

SB-204070 hydrochloride

solid, ≥97% (HPLC)

Synonym(s):

(1-Butyl-4-piperidinyl)methyl-8-amino-7-chloro-1,4-benzodioxane-5-carboxylate hydrochloride

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Size/SKUAvailabilityPrice
5 mg
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$781.00

About This Item

Empirical Formula (Hill Notation):
C19H27ClN2O4 · HCl
CAS Number:
Molecular Weight:
419.34
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥97% (HPLC)
Form:
solid

$781.00


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Quality Segment

assay

≥97% (HPLC)

form

solid

mp

243-245 °C (lit.)

solubility

H2O: 20 mg/mL (with heating)

SMILES string

Cl[H].CCCCN1CCC(CC1)COC(=O)c2cc(Cl)c(N)c3OCCOc23

InChI

1S/C19H27ClN2O4.ClH/c1-2-3-6-22-7-4-13(5-8-22)12-26-19(23)14-11-15(20)16(21)18-17(14)24-9-10-25-18;/h11,13H,2-10,12,21H2,1H3;1H

InChI key

YEQGKAOSYSXEPU-UHFFFAOYSA-N

Gene Information

human ... HTR4(3360)

Application

SB-204070 hydrochloride was used to study the role of 5-HT metabolites in trypsin-induced anion secretion in mouse cecum.

Biochem/physiol Actions

SB-204070 is a highly potent and specific antagonist of 4-HT4 receptor. It inhibits cholinergic and noncholinergic transmission and blocks the contractions of proximal colon in guinea pigs and relaxation of human colon circular smooth muscle.
Selective 5-HT4 serotonin receptor antagonist.

Legal Information

Manufactured and sold under exclusive license from GlaxoSmithKline Pharmaceuticals

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This Item
S7389
description

solid, ≥97% (HPLC)

description

powder, ≥98% (HPLC)

assay

≥97% (HPLC)

assay

≥98% (HPLC)

form

solid

form

powder

Quality Level

100

Quality Level

100

solubility

H2O: 20 mg/mL (with heating)

solubility

H2O: 10 mg/mL, clear (warmed to 60 °C)

mp

243-245 °C (lit.)

mp

-

Gene Information

human ... HTR4(3360)

Gene Information

human ... HTR7(3363)


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)



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