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Monoclonal Anti-Spectrin (α and β) antibody produced in mouse

Name: Monoclonal Anti-Spectrin (α and β) antibody produced in mouse
Brand: SIGMA
Price: 397.8 USD
Availability: InStock

clone SB-SP1, ascites fluid

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD00164739

Conjugate:

unconjugated

Clone:

SB-SP1, monoclonal

Application:

ARR, IF, WB

Citations:

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Properties

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

SB-SP1, monoclonal

contains

15 mM sodium azide

species reactivity

human

technique(s)

indirect immunofluorescence: suitable using erythrocyte smears, microarray: suitable, western blot: 1:500 using extract of human erythrocyte ghosts or purified human erythrocyte spectrin

isotype

IgG1

UniProt accession no.

P02549, P11277

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SPTA1(6708), SPTB(6710)

Description

General description

Monoclonal anti-Spectrin (α and β) (mouse IgG1 isotype) is produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Spectrin is a major constituent of the erythrocyte skeleton accounting for 25% of the total membrane protein and 75% of the cytoskeletal mass.

Spectrins are heterotetramers, that are composed of several αand β subunit isoforms. They are the constituents of G-protein-coupled receptor (GPCR) and the synaptic multiprotein complex. α-Spectrin has 20 spectrin repeats (α1-α20) and β-spectrin has 17 spectrin repeats (β1-β17). SPTA1 (spectrin α 1) is located on chromosome 1q21–q23 and SPTB (spectrin β) is located on chromosome 14q22–q23.2.

Immunogen

human erythrocyte spectrin.

Application

Anti-Spectrin (α and β) antibody has been used in western blotting and immunostaining.

Monoclonal Anti-Spectrin (α and β) antibody produced in mouse has been used in flow cytometry analysis and confocal microscopy.

Biochem/physiol Actions

Spectrins are multifunctional proteins, that modulates the cell morphology and mechanical properties. Spectrins also participates in the cell cycle by controlling the upregulation of membrane receptors. α- and β-spectrins are essential for the development of nervous system.

This antibody reacts specifically with the α and β chains of human erythrocyte spectrin.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	S1515	ZRB2080	ZRB1650
Sigma-Aldrich S3396 Monoclonal Anti-Spectrin (α and β) antibody produced in mouse	Sigma-Aldrich S1515 Anti-Spectrin antibody produced in rabbit	Sigma-Aldrich ZRB2080 Anti-Spectrin α Antibody, clone 1D4 ZooMAb^® Rabbit Monoclonal	Sigma-Aldrich ZRB1650 Anti-Spectrin α Antibody, clone 2G17 ZooMAb^® Rabbit Monoclonal
description clone SB-SP1, ascites fluid	description whole antiserum	description recombinant, expressed in HEK 293 cells	description recombinant, expressed in HEK 293 cells
species reactivity human	species reactivity human	species reactivity mouse, rat, human	species reactivity mouse, human, rat
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
biological source mouse	biological source rabbit	biological source rabbit	biological source rabbit
Gene Information human ... SPTA1(6708), SPTB(6710)	Gene Information human ... SPTA1(6708), SPTB(6710), SPTBN1(6711), SPTBN2(6712), SPTBN4(57731), SPTBN5(51332)	Gene Information human ... SPTAN1(6709)	Gene Information -
clone SB-SP1, monoclonal	clone polyclonal	clone 1D4, recombinant monoclonal	clone 2G17, recombinant monoclonal
antibody form ascites fluid	antibody form whole antiserum	antibody form purified antibody	antibody form purified antibody

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Storage Class

12 - Non Combustible Liquids

WGK

nwg

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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