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S3442

SB 216763

>98% (HPLC), glycogen synthase kinase-3 inhibitor

Synonym(s):

3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$212.00
25 mg

Available to ship TODAYfromMILWAUKEE

$808.00

About This Item

Empirical Formula (Hill Notation):
C19H12N2O2Cl2
CAS Number:
Molecular Weight:
371.22
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
>98% (HPLC)

$212.00


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Product Name

SB 216763, >98% (HPLC)

Quality Segment

assay

>98% (HPLC)

color

orange

solubility

DMSO: soluble 20 mg/mL, H2O: insoluble

originator

GlaxoSmithKline

storage temp.

−20°C

SMILES string

Cn1cc(C2=C(C(=O)NC2=O)c3ccc(Cl)cc3Cl)c4ccccc14

InChI

1S/C19H12Cl2N2O2/c1-23-9-13(11-4-2-3-5-15(11)23)17-16(18(24)22-19(17)25)12-7-6-10(20)8-14(12)21/h2-9H,1H3,(H,22,24,25)

InChI key

JCSGFHVFHSKIJH-UHFFFAOYSA-N

Gene Information

Application

SB-216763 was used to inhibit GSK-3β in human brain microvascular endothelial cell line and colorectal cancer cells.

Biochem/physiol Actions

SB-216763 is a small molecule that competes with ATP and potently inhibits the activity α and β isozymes of GSK-3. It acts as neuroprotectant and prevents neuronal cell death induced by PI3-kinase pathway. It also delays preconditioning, reduces infarct size and prevents cardiac ischemia.
Potent, selective, cell permeable glycogen synthase kinase-3 (GSK-3) inhibitor.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the GSK-3 and PKB/Akt pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Legal Information

Sold for research purposes under agreement from Glaxo­Smith­Kline

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This Item
361566SML0084S3567
description

>98% (HPLC)

description

-

description

≥98% (HPLC)

description

≥98% (HPLC)

assay

>98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: soluble 20 mg/mL, H2O: insoluble

solubility

DMSO: 50 mg/mL

solubility

DMSO: ≥9 mg/mL

solubility

DMSO: 5 mg/mL, clear, H2O: insoluble

color

orange

color

orange

color

yellow-orange

color

yellow to orange

originator

GlaxoSmithKline

originator

-

originator

-

originator

GlaxoSmithKline


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

dust mask type N95 (US), Eyeshields, Gloves



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