Yes. After dissolving this product in DMSO, the stock solution can be sterilized using a sterile 0.22 µm syringe filter, as long as the filter membrane/housing is compatible with DMSO. This product is soluble in DMSO at 10 mg/mL and insoluble in water. For filtration, use a DMSO-compatible filter, preferably regenerated cellulose (RC) or PTFE; avoid membranes that may leach, swell, or reduce compound recovery.
S4317
SB 431542 hydrate
≥98% (HPLC), powder, inhibits activation of SMAD proteins
Synonym(s):
4-(5-Benzol[1,3]dioxol-5-yl-4-pyrldin-2-yl-1H-imidazol-2-yl)-benzamide hydrate, 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]-benzamide hydrate, 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]-benzamide hydrate
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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Available to ship TODAYfromMILWAUKEE | $212.00 |
About This Item
Empirical Formula (Hill Notation):
C22H16N4O3 · xH2O
CAS Number:
Molecular Weight:
384.39 (anhydrous basis)
UNSPSC Code:
51111800
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Product Name
SB 431542 hydrate, ≥98% (HPLC), powder
Quality Segment
assay
≥98% (HPLC)
form
powder
solubility
DMSO: soluble 10 mg/mL, H2O: insoluble
originator
GlaxoSmithKline
storage temp.
−20°C
SMILES string
O.NC(=O)c1ccc(cc1)-c2nc(-c3ccc4OCOc4c3)c([nH]2)-c5ccccn5
InChI
1S/C22H16N4O3.H2O/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17;/h1-11H,12H2,(H2,23,27)(H,25,26);1H2
InChI key
WQUIJVKNPYBZOF-UHFFFAOYSA-N
Application
Biochem/physiol Actions
SB-431542 inhibits the TGF-β-mediated activation of SMAD proteins, expression of collagen and fibronectin, cell proliferation and cell motility. It does not inhibit kinases that are activated in response to serum or stress such as ERK, p38 or JNK.
Potent and selective inhibitor of transforming growth factor-β superfamily type I activin receptor-like kinase (ALK) receptors.
Features and Benefits
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Legal Information
Sold for research purposes under agreement from GlaxoSmithKline
1 of 1
This Item | ||
|---|---|---|
| description ≥98% (HPLC), powder | description InSolution, ≥97% | description TGF-β RI Kinase Inhibitor VI, SB431542, CAS 301836-41-9, is a cell-permeable inhibitor of SMAD2 phosphorylation. Inhibits the activity of ALK4 and ALK5 (IC50 = 140 nM and 94 nM, respectively). |
| assay ≥98% (HPLC) | assay ≥97% (HPLC) | assay ≥97% (HPLC) |
| form powder | form liquid | form solid |
| Quality Level 300 | Quality Level 100 | Quality Level 300 |
| storage temp. −20°C | storage temp. −20°C | storage temp. 2-8°C |
| solubility H2O: insoluble, DMSO: soluble 10 mg/mL | solubility - | solubility ethanol: 10 mg/mL, DMSO: 100 mg/mL |
| originator GlaxoSmithKline | originator - | originator - |
Storage Class
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
PPE (personal protective equipment)
Eyeshields, Gloves, type N95 (US)
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After dissolving in DMSO to a stock concentration, is it OK to sterile with 0.22μm syringe filter?
1 answer-
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Is it okay to store the original product and its aliquoted stock solutions not only at -20℃ specifically, but also in some temperature range around -20℃? Can I have certain temperature range for storage?
1 answer-
The acceptable temperature range for products stored at -20°C is -10°C to -25°C. The stability of this product in solution has not been investigated. However, external sources indicate that stock solutions prepared in DMSO are stable for 6 months when stored at -20°C. The same acceptable range would apply.
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If not reconstituted for how long can I store the vial?
1 answer-
This product is not assigned an expiration date or recommended retest date. Products with no expiration date or recommended retest date should be routinely inspected by customers to ensure they perform as expected. These products are also subject to a one-year warranty from the date of shipment. For more information, you may access the Product Dating Information document under ADDITIONAL USEFUL DOCUMENTS ABOUT OUR PRODUCTS at the bottom of the Quality Services page with this link: https://www.sigmaaldrich.com/life-science/quality-and-regulatory-management/quality-services.
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How long can I store the reconstituted compound in the freezer -20 degrees? i have one that was aliquoted 4 years ago. Is it still ok to use it ?
1 answer-
It is recommended, following reconstitution, to aliquot and freeze -20°C. The stock solutions are stable for up to 6 months at -20°C. The quality of solutions stored frozen for extended periods has not been evaluated. The end user would have to determine suitability. Any color change, cloudiness, or particulate matter present upon thawing would be a visual indicator of degradation.
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