S4326
SB-277011-A hydrochloride hydrate
≥98% (HPLC)
Select a Size
| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Estimated to ship onAugust 14, 2026fromMILWAUKEE | $186.00 |
25 mg | Available to ship TODAYfromMILWAUKEE | $509.00 |
About This Item
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
protect from light
color
white to beige
solubility
DMSO: 2 mg/mL, clear (warmed)
originator
GlaxoSmithKline
storage temp.
2-8°C
SMILES string
O.Cl.O=C(N[C@@H]1CC[C@H](CC1)CCN2CCc3cc(ccc3C2)C#N)c4ccnc5ccccc45
InChI
1S/C28H30N4O.ClH.H2O/c29-18-21-5-8-23-19-32(16-13-22(23)17-21)15-12-20-6-9-24(10-7-20)31-28(33)26-11-14-30-27-4-2-1-3-25(26)27;;/h1-5,8,11,14,17,20,24H,6-7,9-10,12-13,15-16,19H2,(H,31,33);1H;1H2/t20-,24-;;
InChI key
OOWNBQACGIKNGM-ONAIBGCWSA-N
Application
- as a dopamine D3 receptor-selective antagonist in rats to test its effect on 4-propyl-9-hydroxynaphthoxazine ([3H]-(+)-PHNO) radiotracer in cerebellum L9/10 and striatumPMID 25837930
- as an acetylcholine inhibitor to test its negative allosteric modulation on Ascaris suum nicotinic acetylcholine receptor (Asu-ACR-16) expressed in Xenopus oocytes and its inhibitory effect on locomotion in Caenorhabditis elegansPMID 27054065
- to test its effect on alcohol consumption in micePMID 25257287
Biochem/physiol Actions
Features and Benefits
1 of 1
This Item | |||
|---|---|---|---|
| description ≥98% (HPLC) | description powder, ≥98% (HPLC) | description ≥98% (HPLC) | description ≥98% (HPLC) |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| form powder | form powder | form powder | form powder |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| storage condition protect from light | storage condition desiccated | storage condition desiccated | storage condition - |
| solubility DMSO: 2 mg/mL, clear (warmed) | solubility H2O: 10 mg/mL, clear (warmed to 60 °C) | solubility DMSO: >10 mg/mL, H2O: insoluble | solubility H2O: 1 mg/mL, clear (warmed) |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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