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S4451

Sal003

≥98% (HPLC)

Synonym(s):

(2E)-3-Phenyl-N-[2,2,2-trichloro-1-[[[(4-chlorophenyl)amino]thioxomethyl]amino]ethyl]-2-propenamide, 3-Phenyl-N-(2,2,2-trichloro-1-((((4-chlorophenyl)amino)carbonothioyl)amino)ethyl)acrylamide

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$170.00

About This Item

Empirical Formula (Hill Notation):
C18H15Cl4N3OS
CAS Number:
Molecular Weight:
463.21
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated, protect from light

$170.00


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Quality Segment

assay

≥98% (HPLC)

form

powder

storage condition

desiccated, protect from light

color

white to off-white

solubility

DMSO: ≥10 mg/mL

compatibility

for use with Bio-Rad CFX96

storage temp.

2-8°C

SMILES string

Clc1ccc(NC(=S)NC(NC(=O)\C=C\c2ccccc2)C(Cl)(Cl)Cl)cc1

InChI

1S/C18H15Cl4N3OS/c19-13-7-9-14(10-8-13)23-17(27)25-16(18(20,21)22)24-15(26)11-6-12-4-2-1-3-5-12/h1-11,16H,(H,24,26)(H2,23,25,27)/b11-6+

InChI key

TVNBASWNLOIQML-IZZDOVSWSA-N

Application

Sal003 was used to study the role of eIF2α in Subtilase cytotoxin-induced apoptosis in HeLa cells.

Biochem/physiol Actions

Sal003 inhibits the late long-term potentiation (L-LTP) and long-term memory formation in mammalian hippocampal slices. The effect of Sal003 on L-LTP is mediated by the transcription factor, ATF4.
Sal003 is a potent and cell-permeable eIF-2a phosphatase inhibitor.

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This Item
324896SML2264SML0625
description

≥98% (HPLC)

description

The eIF-2α Inhibitor II, Sal003, also referenced under CAS 301359-91-1, controls the biological activity of eIF-2α. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

description

≥98% (HPLC)

description

≥95% (HPLC)

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

≥98% (HPLC)

assay

≥95% (HPLC)

form

powder

form

solid

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

100

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage condition

protect from light, desiccated

storage condition

protect from light, OK to freeze

storage condition

-

storage condition

-

solubility

DMSO: ≥10 mg/mL

solubility

DMSO: 10 mg/mL

solubility

DMSO: 2 mg/mL, clear

solubility

-


Pictograms

Environment

Signal Word

Warning

Hazard Codes

Precautionary Statements

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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