Skip to Content
MilliporeSigma

Skip To

S4503

DL-Serine hydroxamate

≥97% (TLC), suitable for ligand binding assays

Synonym(s):

SHX

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Size/SKUAvailabilityPrice
250 mg
Check Cart for Availability
$609.00
1 g
Check Cart for Availability
$2,100.00

About This Item

Empirical Formula (Hill Notation):
C3H8N2O3
CAS Number:
Molecular Weight:
120.11
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.26
MDL number:

$609.00


Check Cart for Availability

​
Request a Custom Order
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist


Product Name

DL-Serine hydroxamate, seryl-tRNA synthetase inhibitor

Quality Segment

assay

≥97% (TLC)

form

powder

technique(s)

ligand binding assay: suitable

color

white to off-white

application(s)

cell analysis

storage temp.

−20°C

SMILES string

NC(CO)C(=O)NO

InChI

1S/C3H8N2O3/c4-2(1-6)3(7)5-8/h2,6,8H,1,4H2,(H,5,7)

InChI key

LELJBJGDDGUFRP-UHFFFAOYSA-N

Application

Serine has been used as an inhibitor of seryl-tRNA synthetase. DL-Serine hydroxamate is used to induce metabolic synthesis of guanosine 3′-diphosphate 5′-diphosphate (ppGpp) in E. coli by amino acid starvation. It is also used to synchronize cell cycle in E. coli cultures by inhibition of tRNA charging.

Biochem/physiol Actions

Serine is involved in the one-carbon unit metabolism. It is associated with the biosynthesis of cysteine, ceramide, phosphatidylserine, purine and pyrimidine. In bacteria, it participates in tryptophan synthesis. Gluconeogenesis, one of the important biochemical processes, involves serine, particularly in ruminants. Protein phosphorylation is one such event that utilizes serine. Glycine, a metabolic product of serine, serves as an antioxidant and a neurotransmitter. D-serine is known to activate the N-methyl-D-aspartate (NMDA) receptors of the brain. Serine hydroxamate, a structural analogue of serine prevents seryl-tRNA (transfer ribonucleic acid) charging and thereby decreases phospholipid and nucleic acid synthesis in Escherichia coli.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
S4375S5386223131
description

seryl-tRNA synthetase inhibitor

description

≥98% (TLC)

description

BioReagent, suitable for cell culture, suitable for insect cell culture, ≥98% (HPLC)

description

98%

form

powder

form

powder

form

powder

form

powder

technique(s)

ligand binding assay: suitable

technique(s)

-

technique(s)

cell culture | insect: suitable, cell culture | mammalian: suitable

technique(s)

-

assay

≥97% (TLC)

assay

≥98% (TLC)

assay

≥98% (HPLC)

assay

98%

storage temp.

−20°C

storage temp.

-

storage temp.

-

storage temp.

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

100

color

white to off-white

color

white

color

white

color

-


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)



Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library




Questions

Reviews

No rating value

Active Filters