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S4568

SCH 58261

≥98% (HPLC), adenosine receptor antagonist, solid

Synonym(s):

7-(2-phenylethyl)-5-amino-2-(2-furyl)-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidine

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Size/SKUAvailabilityPrice
5 mg
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$221.00
25 mg
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$839.00
$713.15

About This Item

Empirical Formula (Hill Notation):
C18H15N7O
CAS Number:
Molecular Weight:
345.36
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
solid

$221.00


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Product Name

SCH 58261, ≥98% (HPLC), solid

Quality Segment

assay

≥98% (HPLC)

form

solid

color

off-white

solubility

DMSO: soluble >10 mg/mL, H2O: insoluble

SMILES string

Nc1nc2n(CCc3ccccc3)ncc2c4nc(nn14)-c5ccco5

InChI

1S/C18H15N7O/c19-18-22-16-13(11-20-24(16)9-8-12-5-2-1-3-6-12)17-21-15(23-25(17)18)14-7-4-10-26-14/h1-7,10-11H,8-9H2,(H2,19,22)

InChI key

UTLPKQYUXOEJIL-UHFFFAOYSA-N

Application

SCH 58261 was used to block A2α adenosine receptor to study the signaling by prostatic acid phosphatase in neurons.4

Biochem/physiol Actions

SCH 58261 reduces the levels of TNF-α, Fas-L, Bax expression and activation of JNK-MAPK pathway. It has neuroprotective effects as it reduces demyelination of the neurons. SCH 58261 increases the concentration of secretion of dopamine and elicits locomotor sensitization, an attractive option in the possible treatment of Parkinson′s disease.
A2A adenosine receptor antagonist.

Features and Benefits

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item
119150D7815D0444
description

≥98% (HPLC), solid

description

-

description

≥98% (HPLC), powder

description

≥95% (HPLC), film

form

solid

form

(Off-white solid)

form

powder

form

film

assay

≥98% (HPLC)

assay

-

assay

≥98% (HPLC)

assay

≥95% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

200

solubility

H2O: insoluble, DMSO: soluble >10 mg/mL

solubility

soluble (100 mM in DMSO)

solubility

DMSO: 10 mg/mL, clear, H2O: insoluble

solubility

H2O: 0.5 mg/mL, clear

color

off-white

color

-

color

white

color

colorless to white


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)



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