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Anti-α1-Syntrophin (RA-16) antibody produced in rabbit

Name: Anti-α1-Syntrophin (RA-16) antibody produced in rabbit
Brand: SIGMA
Price: 472.6 USD
Availability: InStock

buffered aqueous solution, IgG fraction of antiserum

Synonym(s):

Anti-SNTA1

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Size/SKU	Availability	Price
0.2 mL	Available to ship TODAYfromMILWAUKEE	$556.00 $472.60

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD03454688

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ARR, IHC (f), WB

Citations:

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Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 60 kDa

species reactivity

rat

technique(s)

immunohistochemistry (frozen sections): suitable using 0.5% paraformaldehyde fixed/0.5% Triton X-100 treated rat skeletal muscle, microarray: suitable, western blot: 1:2,000 using rat skeletal muscle homogenate extract (membrane fraction)

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... Snta1(20648)
rat ... Snta1(362242)

Description

General description

α1-syntrophin (SNTA1) is a dystrophin-associated protein, that has four domains- a postsynaptic density protein-95/disc large/zona occludens-1 (PDZ) domain, two pleckstrin homology (PH1 and PH2) domains and a syntrophin unique (SU) domain. It is located on human chromosome 20q11.2. It is usually present in the peripheral cytoplasmic membrane.

Anti-α1-Syntrophin (RA-16) is developed in rabbit using a synthetic peptide corresponding to a sequence of mouse α1-syntrophin The syntrophins are a family of intracellular peripheral membrane proteins (58-60 kDa), comprising at least three isoforms α1, β1, and β2-syntrophins. Syntrophins in mammalian skeletal muscle have been shown to be part of a complex of proteins associated with dystrophin, the product of Duchenne/Becker muscular dystrophy gene. The C-terminal 57 amino acids region of syntrophins is highly conserved among the three isoforms, and may contain the binding site for dystrophin.

Immunogen

synthetic peptide corresponding to a sequence of mouse α1-syntrophin (amino acids 191-206 with N-terminally added lysine) conjugated to KLH.

Application

Anti-α1-Syntrophin (RA-16) antibody produced in rabbit has been used in immunohistochemistry and immunoblotting.

Biochem/physiol Actions

α1-Syntrophin recruit signaling proteins(2) to the membrane via association with the dystrophin complex.

α1-syntrophin (SNTA1) mutations results in LQTS (cardiac channelopathies like long QT syndrome). It modulates the development of adipocyte lipid droplet. It also participates in the survival signaling pathway in myoblasts. α1-syntrophin controls voltage-gated Na+ channels. It acts as a substrate for stress-activated protein kinase-3 (SAPK-3).

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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$Anti-α1-Syntrophin (RA-16) antibody produced in rabbit buffered aqueous solution, IgG fraction of antiserum$ Sigma-Aldrich S4813 Anti-α1-Syntrophin (RA-16) antibody produced in rabbit	$Anti-VGLUT1 antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich V0389 Anti-VGLUT1 antibody produced in rabbit	$Anti-MAGI-2 antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich M2441 Anti-MAGI-2 antibody produced in rabbit	$Anti-Substance P Receptor antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich S8305 Anti-Substance P Receptor antibody produced in rabbit
description buffered aqueous solution, IgG fraction of antiserum	description IgG fraction of antiserum, buffered aqueous solution	description IgG fraction of antiserum, buffered aqueous solution	description IgG fraction of antiserum, buffered aqueous solution
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
antibody form IgG fraction of antiserum	antibody form IgG fraction of antiserum	antibody form IgG fraction of antiserum	antibody form IgG fraction of antiserum
species reactivity rat	species reactivity human	species reactivity rat	species reactivity human, rat, mouse, guinea pig
mol wt antigen 60 kDa	mol wt antigen 60 kDa	mol wt -	mol wt antigen 46 kDa

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Storage Class

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

088M4840V

061K4885

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