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Anti-SGK antibody produced in rabbit

Name: Anti-SGK antibody produced in rabbit
Brand: SIGMA
Price: 584 USD
Availability: InStock

buffered aqueous solution, IgG fraction of antiserum

Synonym(s):

Anti-SGK

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Size/SKU	Availability	Price
0.2 mL	Estimated to ship TODAYfromMILWAUKEE	$584.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.44

MDL number:

MFCD02686615

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ARR, IF, WB

Citations:

$584.00

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Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 50 kDa

species reactivity

human

technique(s)

indirect immunofluorescence: 1:2,000 using 3% paraformaldehyde-fixed, 0.5% Triton X-100 treated human epidermal carcinoma A431cell line, microarray: suitable, western blot: 1:2,000 using whole cell extract of the human epidermal carcinoma A431 cell line

UniProt accession no.

O00141

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... SGK1(6446)

Description

General description

Anti-SGK is developed in rabbit using a synthetic peptide corresponding to the C-terminus of human SGK conjugated to KLH (keyhole limpet hemocyanin). SGK is localized to the perinuclear or cytoplasmic compartment as a hypophosphorylated protein.

SGK (serum and glucocorticoid-regulated protein kinase) is a 50 kDa member of Ser/Thr kinase family. Sequence of sgk is well conserved across species, the human and rat SGK amino acid sequences are 96-98% identical.

Application

Anti-SGK antibody produced in rabbit has been used in :

immunoprecipitation
western blotting
immunofluorescence

Biochem/physiol Actions

SGK (serum and glucocorticoid-regulated protein kinase) plays an important role in signal transduction activated by mineral corticoids. It is also regulated at the transcription level by stimuli including glucocorticoid, serum, follicle stimulating hormone as well as changes in cell volume. SGK levels are strongly affected by osmotic changes. SGK is strongly and rapidly stimulated in kidney cells in response to aldosterone and stimulates epithelial Na⁺ channels, suggesting a central role of SGK in the regulation of sodium transport and homeostasis. SGK transcription is markedly increased in diabetic nephropathy, in response to excessive extracellular glucose concentrations. The localization of SGK in the cell is regulated by hormones or serum. For cell cycle progression, the shuttling of SGK between nucleus and cytoplasm is required.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	SAB4502765	SAB5700669	HPA051251
$Anti-SGK antibody produced in rabbit buffered aqueous solution, IgG fraction of antiserum$ Sigma-Aldrich S5188 Anti-SGK antibody produced in rabbit	Sigma-Aldrich SAB4502765 Anti-SGK antibody produced in rabbit	Sigma-Aldrich SAB5700669 Anti-SGK1 antibody produced in rabbit	Sigma-Aldrich HPA051251 Anti-SGK1 antibody produced in rabbit
description buffered aqueous solution, IgG fraction of antiserum	description affinity isolated antibody	description -	description Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 100
antibody form IgG fraction of antiserum	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
species reactivity human	species reactivity human, rat, mouse	species reactivity human, rat, mouse	species reactivity human
Gene Information human ... SGK1(6446)	Gene Information human ... SGK1(6446)	Gene Information human ... SGK1(6446)	Gene Information human ... SGK1(6446)

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Storage Class

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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