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Monoclonal Anti-S100A2 antibody produced in mouse

Name: Monoclonal Anti-S100A2 antibody produced in mouse
Brand: SIGMA
Price: 624.75 USD
Availability: InStock

clone SH-L1, ascites fluid

Synonym(s):

Anti-S100L

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Size/SKU	Availability	Price
0.2 mL	Check Cart for Availability	$735.00 $624.75

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD00677383

Conjugate:

unconjugated

Clone:

SH-L1, monoclonal

Application:

IF, IHC (f), IHC (p), IP, WB

Citations:

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Properties

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

SH-L1, monoclonal

contains

15 mM sodium azide

species reactivity

lizard, goat, rat, bovine, human, feline, frog, canine, pig

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, immunohistochemistry (frozen sections): suitable, immunoprecipitation (IP): suitable using native preparations, indirect immunofluorescence: 1:1,000 using cultured Madin-Darby bovine kidney (MDBK) cells, western blot: 1:1,000

isotype

IgG1

UniProt accession no.

P29034

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... S100A2(6273)

Description

General description

Monoclonal Anti-S100A2 (S100L) (mouse IgG1 isotype) is derived from the SH-L1 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice. S-100² is a set of small, thermolabile, highly acidic 10-20 kDa dimer proteins that are widely distributed in different tissues. The S-100 family consists of at least 10 members with a cell-type-specific expression pattern. It is a calcium-modulated protein. S100A2 is also called S100L. S100A2 has been shown to possess 43-47% homology with S-100α, S-100β and Calcyclin. It is expressed at high levels in kidney and lung, intermediate levels in muscle and low levels in brain and intestine.

Immunogen

Ca²⁺-binding proteins from pig stomach tissue

Application

Monoclonal Anti-S100A2 antibody has been used in enzyme linked immunosorbent assay (ELISA), immunoblotting, immunoprecipitation, immunohistology, western blotting.

Biochem/physiol Actions

S-100 binds to calcium and zinc ions reversibly at physiologic pH and ionic strength, followed by a conformational change in the molecule. S-100 is a cell-growth regulator, increasing the membrane permeability to cations under physiologic conditions, stimulation of nucleolar RNA polymerase activity, interaction with the tumor suppressor protein p53 and as a carrier of proteins and free fatty acids in adipocytes. High levels of S100A2 are found also in the MDBK (Madin-Darby bovine kidney) cell line and in human glioma.

The antibody recognizes an epitope located on S100A2 (S100L is the old terminology) in a Ca²⁺ ion-dependent manner. The product does not react with other members of the EF-hand family such as calmodulin, parvalbumin, intestinal calcium-binding protein, S100A6 (calcyclin), caltropin, the α chain of S-100 (i.e. in S-100a and S-100ao), or the β chain (i.e. in S-100a and S-100b).

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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1 of 1

This Item	S2657	WH0006282M1	WH0006271M1
Sigma-Aldrich S6797 Monoclonal Anti-S100A2 antibody produced in mouse	Sigma-Aldrich S2657 Anti-S-100 (β-Subunit) antibody, Mouse monoclonal	Sigma-Aldrich WH0006282M1 Monoclonal Anti-S100A11 antibody produced in mouse	Sigma-Aldrich WH0006271M1 Monoclonal Anti-S100A1 antibody produced in mouse
description clone SH-L1, ascites fluid	description clone SH-B4, purified from hybridoma cell culture	description clone 2F4, purified immunoglobulin, buffered aqueous solution	description clone 1D5, purified immunoglobulin, buffered aqueous solution
Gene Information human ... S100A2(6273)	Gene Information human ... S100B(6285) rat ... S100b(25742)	Gene Information human ... S100A11(6282)	Gene Information human ... S100A1(6271)
clone SH-L1, monoclonal	clone SH-B4, monoclonal	clone 2F4, monoclonal	clone 1D5, monoclonal
antibody form ascites fluid	antibody form (Solution in 0.01M phosphate buffered saline pH 7.4, containing 15mM sodium azide as a preservative)	antibody form purified immunoglobulin	antibody form purified immunoglobulin
biological source mouse	biological source mouse	biological source mouse	biological source mouse
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
species reactivity lizard, goat, rat, bovine, human, feline, frog, canine, pig	species reactivity sheep, bovine, goat, pig, feline, rabbit, rat, canine, human	species reactivity human	species reactivity human

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Storage Class

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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