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S7817

Scriptaid

synthetic (organic), ≥95%, Histone deacetylase inhibitor, solid

Synonym(s):

6-(1,3-Dioxo-1H, 3H-benzo[de]isoquinolin-2-yl)-hexanoic acid hydroxyamide

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Size/SKUAvailabilityPrice
1 mg

Available to ship TODAYfromMILWAUKEE

$170.00
5 mg

Available to ship TODAYfromMILWAUKEE

$578.00

About This Item

Empirical Formula (Hill Notation):
C18H18N2O4
CAS Number:
287383-59-9
Molecular Weight:
326.35
UNSPSC Code:
12352203
PubChem Substance ID:
329824590
NACRES:
NA.77
MDL number:
MFCD00386477
Assay:
≥95%
Form:
solid

$170.00

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Product Name

Scriptaid, ≥95%, solid

biological source

synthetic (organic)

Quality Segment

assay

≥95%

form

solid

mp

160-161 °C

solubility

DMSO:methanol (1:1): complete 2 mg/ml, clear, colorless to faintly yellow, DMSO: 1 mg/mL, methanol: soluble

storage temp.

−20°C

SMILES string

ONC(=O)CCCCCN1C(=O)c2cccc3cccc(C1=O)c23

InChI

1S/C18H18N2O4/c21-15(19-24)10-2-1-3-11-20-17(22)13-8-4-6-12-7-5-9-14(16(12)13)18(20)23/h4-9,24H,1-3,10-11H2,(H,19,21)

InChI key

JTDYUFSDZATMKU-UHFFFAOYSA-N

General description

Scriptaid is a histone deacetylase (HDAC) inhibitor, which enhances global acetylation of histones. It improves transcriptional activity and protein expression. Scriptaid inhibits tumor growth. It decreases telomerase activity and stimulates glioma cell apoptosis.

Application

Scriptaid has been used in post activation of oocytes and embryo culture.
Scriptaid was used to enhance transcriptional activity in cloning procedures by somatic cell nuclear transfer.5,6

Biochem/physiol Actions

Histone deacetylase inhibitor with lower toxicity than trichostatin A.
Histone deacetylase inhibitor with lower toxicity than trichostatin A; used to enhance protein expression.
Scriptaid inhibits the cell cycle progression of ovarian cancer cells by inducing arrest in G0/G1 and/or G2/M phase. Treatment of cells with scriptaid results in loss of mitochondrial membrane potential and increased acetylation of H3 and H4 histone tails.2 Sciptaid induces expression of γ-globin in human erythroid progenitors via p38 signaling and may be a treatment option for sickle cell disease.3 It enhances the transcriptional activity and protein expression in mouse embryos. This is useful in producing cloned, inbred mouse embryos that develop normally into adulthood with regular reproductive ability.4

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Legal Information

Sold under license of U.S. Patent No. 6,544,957.

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This Item
BP050TRANSRTROB1150000
Scriptaid ≥95%, solid

Sigma-Aldrich

S7817

Scriptaid

Bromocriptine mesilate British Pharmacopoeia (BP) Reference Standard

BP050

Bromocriptine mesilate

Transcriptor Reverse Transcriptase

Roche

TRANSRTRO

Transcriptor Reverse Transcriptase

vibrant-m

B1150000

Bromocriptine mesilate

description

≥95%, solid

description

British Pharmacopoeia (BP) Reference Standard

description

-

description

European Pharmacopoeia (EP) Reference Standard

assay

≥95%

assay

-

assay

≥90% (SDS-PAGE)

assay

-

form

solid

form

powder

form

liquid

form

-

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C (−15°C to −25°C)

storage temp.

−20°C

solubility

methanol: soluble, DMSO: 1 mg/mL, DMSO:methanol (1:1): complete 2 mg/ml, clear, colorless to faintly yellow

solubility

-

solubility

water: miscible

solubility

-

mp

160-161 °C

mp

-

mp

-

mp

-

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Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)

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