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S8160

Superoxide Dismutase from bovine liver

lyophilized powder, ≥1500 units/mg protein

Synonyme(s) :

SOD, Superoxide: superoxide oxidoreductase

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A propos de cet article

Numéro CAS:
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
232-943-0
MDL number:
Numéro CE :
Specific activity:
≥1500 units/mg protein

157.00 CHF


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form

lyophilized powder

Quality Segment

specific activity

≥1500 units/mg protein

mol wt

32.5 kDa

composition

Protein, ≥70% biuret

UniProt accession no.

storage temp.

−20°C

Gene Information

cow ... SOD1(281495)

General description

Research area: Cell signalingSuperoxide Dismutase (SOD), a low molecular weight protein that is found in all aerobic cells of microorganisms, plants, and animals. It exists as three distinct families such as manganese SOD, copper–zinc SOD, and extracellular SOD.[1]

Application

Superoxide dismutase from bovine liver has been used in a study to determine that hypercholesterolemia increases endothelial superoxide anion production. [2] Superoxide dismutase from bovine liver has also been used in a study to investigate diazo coupling, subunit interactions, and electrophoretic variants of bovine erythrocyte superoxide dismutase. [3]It has also been used as a component of the assay buffer in thequantification of reactive oxygen species (ROS) by O2k fluorometry.[4]

Biochem/physiol Actions

Superoxide Dismutase catalyzes the dismutation of superoxide radicals to hydrogen peroxide and molecular oxygen. It plays a critical role in the defense of cells against the toxic effects of oxygen radicals. It competes with nitric oxide (NO) for superoxide anion (which reacts with NO to form peroxynitrite), thereby SOD promotes the activity of NO. SOD has also been shown to suppress apoptosis in cultured rat ovarian follicles, neural cell lines, and transgenic mice.

Physical form

Lyophilized powder containing potassium phosphate buffer salts

Analysis Note

For assay method, see McCord, J.M. and Fridovich, I., J. Biol. Chem., 244, 6049 (1969).

Other Notes

One unit will inhibit reduction of cytochrome c by 50% in a coupled system with xanthine oxidase at pH 7.8 at 25 °C in a 3.0 mL reaction volume. Xanthine oxidase concentration should produce an initial ΔA550 of 0.025 ± 0.005 per min.

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Cet article
S8409S7571S7446
Gene Information

cow ... SOD1(281495)

Gene Information

cow ... SOD1(281495)

Gene Information

cow ... SOD1(281495), SOD2(281496)

Gene Information

-

specific activity

≥1500 units/mg protein

specific activity

2,000-6,000 units/mg protein (biuret)

specific activity

≥3,000 units/mg protein

specific activity

≥4,500 units/mg protein

form

lyophilized powder

form

ammonium sulfate suspension

form

lyophilized powder

form

lyophilized powder

mol wt

32.5 kDa

mol wt

32.5 kDa

mol wt

32.5 kDa

mol wt

32.5 kDa

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

UniProt accession no.

P00442

UniProt accession no.

P00442

UniProt accession no.

P00442, P41976

UniProt accession no.

-


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pictograms

Health hazard

signalword

Danger

hcodes

Hazard Classifications

Resp. Sens. 1

Classe de stockage

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)



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