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S8567

SU 4312

≥98% (HPLC)

Synonym(s):

3-(4-Dimethylaminobenzylidenyl)-2-indolinone, 3-[[(4-Dimethyl­amino)phenyl]methylene]-1,3-dihydro-2H-indol-2-one, E/Z mixture

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$156.00
$132.60

About This Item

Empirical Formula (Hill Notation):
C17H16N2O
CAS Number:
Molecular Weight:
264.32
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
Assay:
≥98% (HPLC)
Form:
powder

$132.60

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Quality Segment

assay

≥98% (HPLC)

form

powder

color

orange

solubility

DMSO: >10 mg/mL, H2O: insoluble

storage temp.

2-8°C

SMILES string

CN(C)c1ccc(cc1)\C=C2\C(=O)Nc3ccccc23

InChI

1S/C17H16N2O/c1-19(2)13-9-7-12(8-10-13)11-15-14-5-3-4-6-16(14)18-17(15)20/h3-11H,1-2H3,(H,18,20)/b15-11+

InChI key

UAKWLVYMKBWHMX-RVDMUPIBSA-N

Gene Information

human ... FLT1(2321)

Application

SU 4312 was used to study angiogenesis during development of zebrafish embryos.2

Biochem/physiol Actions

SU 4312 inhibits the neuronal NOS and exhibits neuroprotection against NO-mediated neurotoxicity. It might be effective in treatment of neurodegenerative disorders.1
SU 4312 is a vascular endothelial growth factor (VEGF) receptor protein tyrosine kinase 1/2 and platelet derived growth factor (PDGF) receptor inhibitor.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Other Notes

This product is a mixture of the cis- and trans- isomers. The ratio is about 55:45 based on HPLC.

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This Item
S8442SML0176A9605
description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

form

powder

form

powder

form

powder

form

solid

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

solubility

H2O: insoluble, DMSO: >10 mg/mL

solubility

DMSO: 20 mg/mL, clear (warmed), H2O: insoluble

solubility

DMSO: ≥15 mg/mL

solubility

DMSO: >10 mg/mL, H2O: insoluble

Gene Information

human ... FLT1(2321)

Gene Information

human ... EGFR(1956), FLT1(2321), IGFBP1(3484), IL2(3558), KDR(3791), PDGFRB(5159)
mouse ... Flt1(14254), Kdr(16542)

Gene Information

-

Gene Information

-


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

dust mask type N95 (US), Eyeshields, Gloves



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