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S8825

Salermide

≥98% (HPLC)

Synonym(s):

N-{3-[(2-Hydroxy-naphthalen-1-ylmethylene)-amino]-phenyl}-2-phenyl-propionamide

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Size/SKUAvailabilityPrice
5 mg

Estimated to ship onOctober 09, 2026fromMILWAUKEE

$169.00

About This Item

Empirical Formula (Hill Notation):
C26H22N2O2
CAS Number:
1105698-15-4
Molecular Weight:
394.47
NACRES:
NA.77
PubChem Substance ID:
329824611
UNSPSC Code:
12352200
MDL number:
MFCD12912446
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated

$169.00

Estimated to ship onOctober 09, 2026Details

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Quality Segment

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

yellow

solubility

DMSO: >10 mg/mL

storage temp.

2-8°C

SMILES string

CC(C(=O)Nc1cccc(c1)\N=C\c2c(O)ccc3ccccc23)c4ccccc4

InChI

1S/C26H22N2O2/c1-18(19-8-3-2-4-9-19)26(30)28-22-12-7-11-21(16-22)27-17-24-23-13-6-5-10-20(23)14-15-25(24)29/h2-18,29H,1H3,(H,28,30)/b27-17+

InChI key

HQSSEGBEYORUBY-WPWMEQJKSA-N

Application

Salermide was used to treat human pulmonary artery smooth muscle cells to study the effect of SIRT1 inhibition on expression of atrogin by qPCR.1

Biochem/physiol Actions

Salermide is a novel Sirtuin 1 (Sirt1) and Sirtuin 2 (Sirt2) inhibitor (III histone deacetylases inhibitor). In vitro Salermide has a stronger inhibitory effect on Sirt2 than on Sirt1. Salermide induces massive apoptosis in tumor cells. The activity was ascribed to effect of Salermide to the reactivation of proapoptotic genes epigenetically repressed exclusively in cancer cells by Sirt1. Salermide is a stronger Sirtuin inhibitor than sirtinol (Cat. No.S7942).
Salermide is a novel Sirtuin 1 (Sirt1) and Sirtuin 2 (Sirt2) inhibitor. Salermide reactivates proapoptotic genes epigenetically repressed exclusively in cancer cells by Sirt1.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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S4451SML2739SML0409
Salermide ≥98% (HPLC)

Sigma-Aldrich

S8825

Salermide

Sal003 ≥98% (HPLC)

Sigma-Aldrich

S4451

Sal003

SM1-71-R ≥98% (HPLC)

Sigma-Aldrich

SML2739

SM1-71-R

STF-083010 ≥98% (HPLC)

Sigma-Aldrich

SML0409

STF-083010

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: >10 mg/mL

solubility

DMSO: ≥10 mg/mL

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 5 mg/mL (clear solution)

storage condition

desiccated

storage condition

desiccated, protect from light

storage condition

-

storage condition

-

Storage Class

11 - Combustible Solids

WGK

WGK 3

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