S9564
Amyloid Precursor Protein α, Secreted human
>90% (SDS-PAGE), recombinant, expressed in E. coli (N-terminal histidine tagged), buffered aqueous solution
Synonym(s):
sAPPα
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 25 μg | Check Cart for Availability | $687.00 |
About This Item
General description
The APP (amyloid precursor protein) gene is mapped to human chromosome 21q21.3. It encodes a integral membrane protein. APPα is a soluble protein generated by sequential cleavage with α and γ secretase.
Application
Human amyloid precursor protein α secreted, has been used in enzyme linked immunosorbent assay (ELISA).
Biochem/physiol Actions
Amyloid precursor protein α is an α-secretase-cleaved soluble protein that has been shown to have neuroprotective properties. It is derived from amyloid precursor protein. The protein consists of 612 amino acids. Several G protein-coupled receptors are known to activate α-secretase-dependent processing of APP. It has neuroprotective, neurogenic and neurotrophic functions. Amyloid precursor protein a also stimulates gene expression and protein expression.
Physical form
Solution 0.2 μm filtered, in phosphate buffered saline, pH 7.4.
Preparation Note
Expressed as a soluble protein and purified under non-denaturing conditions.
1 of 1
This Item | |||
|---|---|---|---|
| assay >90% (SDS-PAGE) | assay - | assay ≥95% (HPLC) | assay >90% (SDS-PAGE) |
| recombinant expressed in E. coli (N-terminal histidine tagged) | recombinant expressed in E. coli (N-terminal histidine tagged) | recombinant - | recombinant expressed in E. coli (N-terminal histidine tagged) |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| form buffered aqueous solution | form solution | form powder | form buffered aqueous solution |
| storage temp. −70°C | storage temp. −70°C | storage temp. −20°C | storage temp. −70°C |
| mol wt ~100 kDa by SDS-PAGE | mol wt ~100 kDa by SDS-PAGE | mol wt - | mol wt >18.8 kDa |
Storage Class
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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Luo, J.J., et al.
Neuroscience Research, 63, 410-410 (2001)
In vivo BACE1 inhibition leads to brain A?
lowering and increased a-secretase processing of
APP without effect on Neuregulin-1
lowering and increased a-secretase processing of
APP without effect on Neuregulin-1
Sethu Sankaranarayanan
American Society for Engineering Education (2018)
SnapShot: genetics of Alzheimer?s disease
Guerreiro R, et al.
Cell, 155(4), 968-968 (2013)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| S9564-25UG | 04061838072115 |