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Anti-VPS4A antibody, Mouse monoclonal

Name: Anti-VPS4A antibody, Mouse monoclonal
Brand: SIGMA
Price: 633 USD
Availability: InStock

clone VPS4-110, purified from hybridoma cell culture

Synonym(s):

Anti-SKD1, SKD1A, SKD2, VPS4-1, Anti-Vacuolar protein sorting factor 4A, Anti-hVPS4

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Size/SKU	Availability	Price
200 μL	Available to ship TODAYfromMILWAUKEE	$633.00

About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

VPS4-110, monoclonal

Application:

IP, WB

Citations:

$633.00

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Properties

biological source

mouse

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

VPS4-110, monoclonal

form

buffered aqueous solution

mol wt

antigen ~50 kDa

species reactivity

mouse, canine, bovine, human, rat

concentration

~1.0 mg/mL

technique(s)

immunoprecipitation (IP): suitable, western blot: 1-2 μg/mL using whole extracts of mouse 3T3 or human HEK-293 cells.

isotype

IgG1

UniProt accession no.

Q9UN37

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... VPS4A(27183)
mouse ... Vps4a(116733)
rat ... Vps4a(246772)

Description

General description

Monoclonal Anti-VPS4A (mouse IgG1 isotype) is derived from the hybridoma VPS4-110 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a fragment of human VPS4A, conjugated to KLH.

Vacuolar-protein-sorting factor 4A (VPS4A) is an AAAtype ATPase, encoded by the gene mapped to human chromosome 16q22.1. The encoded protein is a member of vacuolar sorting protein family. The protein is characterized by a canonical AAA ATPase cassette followed by an N-terminal MIT (microtubule interacting and trafficking) domain.

Application

Monoclonal Anti-VPS4A antibody has been used in

immunoblotting
immunoprecipitation
immunolabelling

Biochem/physiol Actions

Vacuolar-protein-sorting factor 4A (VPS4A) plays a vital role in lysosomal/endosomal membrane trafficking. It is also involved in the regulation of exosome biogenesis. Downregulated expression of the gene leads to the development of hepatocellular carcinoma (HCC). Thus, VPS4 is considered to be an effective tumor suppressor for HCC. Mutation of the gene leads to defective multivesicular body formation.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as a preservative.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	SAB1407341	SAB4301637	MABN812
Sigma-Aldrich SAB4200215 Anti-VPS4A antibody, Mouse monoclonal	Sigma-Aldrich SAB1407341 Anti-VPS4A antibody produced in mouse	Sigma-Aldrich SAB4301637 Anti-VPS4A	Sigma-Aldrich MABN812 Anti-VPS4A Antibody, clone 14B1.1
description clone VPS4-110, purified from hybridoma cell culture	description purified immunoglobulin, buffered aqueous solution	description affinity isolated antibody	description clone 14B1.1, from mouse
Gene Information human ... VPS4A(27183) mouse ... Vps4a(116733) rat ... Vps4a(246772)	Gene Information human ... VPS4A(27183)	Gene Information human ... VPS4A(27183)	Gene Information human ... VPS4A(27183)
antibody form purified from hybridoma cell culture	antibody form purified immunoglobulin	antibody form affinity isolated antibody	antibody form purified immunoglobulin
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
species reactivity mouse, canine, bovine, human, rat	species reactivity human	species reactivity human	species reactivity human, rat
clone VPS4-110, monoclonal	clone polyclonal	clone polyclonal	clone 14B1.1, monoclonal
biological source mouse	biological source mouse	biological source rabbit	biological source mouse

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c