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Anti-phospho-TDP-43 (pSer⁴¹⁰) antibody produced in rabbit

Name: Anti-phospho-TDP-43 (pSer<SUP>410</SUP>) antibody produced in rabbit
Brand: SIGMA

~1.0 mg/mL, affinity isolated antibody

Synonym(s):

Anti-phospho-ALS10, Anti-phospho-TAR DNA binding protein 43, Anti-phospho-TARDBP, Anti-phospho-TARDP43

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About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

polyclonal

Application:

Citations:

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Properties

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~43 kDa

species reactivity

mouse, human

concentration

~1.0 mg/mL

technique(s)

western blot: 1-2 μg/mL using HepG2 and NIH3T3 cell lysates

UniProt accession no.

Q13148

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

phosphorylation (pSer410)

Gene Information

human ... TARDBP(23435)
mouse ... Tardbp(230908)

Description

General description

TDP-43 (TAR DNA binding protein) belongs to the family of heterogeneous nuclear ribonucleoproteins (hnRNPs), that binds single stranded RNA. TDP-43 has been implicated in the transcription regulation of HIV. TDP-43 is the major ubiquinated component of cytoplasmic inclusions in frontotemporal lobe degeneration subtype FTLD-U and amyotrophic lateral sclerosis (ALS). TDP-43 is predominantly localized to the nucleus.

Immunogen

synthetic peptide containing phosphorylated Ser410 of human TDP-43, conjugated to KLH. The corresponding sequence is identical in mouse TDP-43.

Application

Anti-phospho-TDP-43 (pSer410) antibody produced in rabbit has been used in immunoblotting.

Biochem/physiol Actions

Pathological TDP-43 forms abnormal inclusions in neuronal perikarya and neurites. Several pathogenic TDP-43 mutations have been identified in familial amyotrophic lateral sclerosis (ALS).

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	SAB4200223	T1705	T1580
Sigma-Aldrich SAB4200224 Anti-phospho-TDP-43 (pSer⁴¹⁰) antibody produced in rabbit	Sigma-Aldrich SAB4200223 Anti-phospho-TDP-43 [pSer409] antibody produced in rabbit	Sigma-Aldrich T1705 Anti-TDP-43 antibody produced in rabbit	Sigma-Aldrich T1580 Anti-TDP-43 (C-terminal) antibody produced in rabbit
description ~1.0 mg/mL, affinity isolated antibody	description ~1.0 mg/mL, affinity isolated antibody	description ~1.5 mg/mL, affinity isolated antibody, buffered aqueous solution	description ~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
clone polyclonal	clone polyclonal	clone polyclonal	clone polyclonal
technique(s) western blot: 1-2 μg/mL using HepG2 and NIH3T3 cell lysates	technique(s) indirect immunofluorescence: 1-2 μg/mL using HeLa cells, western blot: 1-2 μg/mL using HepG2 and A431 cell lysates	technique(s) immunohistochemistry: 5-10 μg/mL using rat, mouse or human kidney, indirect immunofluorescence: 5-10 μg/mL using human HepG2 cells, western blot: 1.5-3.0 μg/mL using human U2OS cell lysates	technique(s) indirect immunofluorescence: 5-10 μg/mL using human HepG2 cells, western blot: 1-2 μg/mL using human U2OS cell lysates, immunohistochemistry: 5-10 μg/mL using rat, mouse, and human kidney
form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous solution

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Storage Class

10 - Combustible liquids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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