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Anti-IKZF1/IKAROS antibody, Mouse monoclonal

Name: Anti-IKZF1/IKAROS antibody, Mouse monoclonal
Brand: SIGMA
Price: 593 USD
Availability: InStock

clone E1.14, purified from hybridoma cell culture

Synonym(s):

Anti-Hs.54452, Anti-IK1, Anti-IKAROS family zinc finger 1, Anti-LYF1, Anti-PRO0758, Anti-ZNFN1A1, Anti-hIk-1

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Size/SKU	Availability	Price
200 μL	Check Cart for Availability	$593.00

About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

E1.14, monoclonal

Application:

FACS, ICC, IF, WB

Citations:

$593.00

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Properties

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

E1.14, monoclonal

form

buffered aqueous solution

mol wt

antigen ~55 kDa

species reactivity

rat, monkey, human, mouse

concentration

~1.0 mg/mL

technique(s)

flow cytometry: suitable, immunocytochemistry: 0.25-0.5 μg/mL using Jurkat cells, indirect immunofluorescence: suitable, western blot: 0.25-0.5 μg/mL using Ramos cells

isotype

IgG2b

UniProt accession no.

Q13422

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... IKZF1(10320)

Description

General description

Monoclonal Anti- IKZF1 (Ikaros family zinc finger protein 1)/IKAROS (mouse IgG2b isotype) is derived from the hybridoma E1.14 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a peptide located at the C-terminus human IKZF1/IKAROS. The IKAROS gene encodes a family of hemopoietic specific zinc finger transcriptional regulator proteins, which binds to specific DNA target sequences consisting of TGGGAA consensus motif.

Immunogen

a peptide located at the C-terminus human IKZF1/IKAROS.

Application

Monoclonal Anti-IKZF1 (Ikaros family zinc finger protein 1)/IKAROS antibody produced in mouse has been used in:

immunoblotting
immunofluorescence
immunohistochemistry
flow cytometry

Biochem/physiol Actions

Ikaros family zinc finger protein 1 (IKZF1)/IKAROS activity is essential for the generation of B cell precursors. Ikaros is essential at the earliest stage of T cell and B cell specification. In adults, however, lymphoid lineages rely on Ikaros at distinct phases of their development. Mutations or polymorphisms are associated with human B-cell acute lymphoblastic leukemia (B-ALL). Ikaros functions as a tumor suppressor in T-cell acute lymphoblastic leukemia (T-ALL) and B-ALL. Ikaros deletion was detected in patients with blast-phase myeloproliferative neoplasms.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Show Differences

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This Item	SAB2101144	SAB4700956	SAB2104298
Sigma-Aldrich SAB4200366 Anti-IKZF1/IKAROS antibody, Mouse monoclonal	Sigma-Aldrich SAB2101144 Anti-IKZF1 antibody produced in rabbit	Sigma-Aldrich SAB4700956 Monoclonal Anti-Ikaros antibody produced in mouse	Sigma-Aldrich SAB2104298 Anti-IKZF1 antibody produced in rabbit
description clone E1.14, purified from hybridoma cell culture	description affinity isolated antibody	description clone 4E9	description affinity isolated antibody
clone E1.14, monoclonal	clone polyclonal	clone 4E9, monoclonal	clone polyclonal
antibody form purified from hybridoma cell culture	antibody form affinity isolated antibody	antibody form purified immunoglobulin	antibody form affinity isolated antibody
Gene Information human ... IKZF1(10320)	Gene Information human ... IKZF1(10320)	Gene Information human ... IKZF1(10320)	Gene Information human ... IKZF1(10320)
species reactivity rat, monkey, human, mouse	species reactivity human, horse	species reactivity human, mouse	species reactivity rat, mouse, human
biological source mouse	biological source rabbit	biological source mouse	biological source rabbit
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated

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Storage Class

10 - Combustible liquids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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