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SAB4502139

Anti-PDGFR α antibody produced in rabbit

affinity isolated antibody

Synonym(s):

α platelet-derived growth factor receptor precursor, CD140a, PDGF-R-α, PDGFR-α, kinase PDGFR-α

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Pack SizeSKUAvailabilityPrice
100 μg
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$741.00

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD01322518
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, IF, IHC
Citations:
5

$741.00

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 122 kDa

species reactivity

rat, human, mouse

concentration

~1 mg/mL

technique(s)

ELISA: 1:5000, immunofluorescence: 1:100-1:500, immunohistochemistry: 1:50-1:100

NCBI accession no.

P16234

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PGFRA(5156)

General description

Anti-PDGFR Anti-PDGFR α Antibody detects endogenous levels of total PDGFR α protein. Antibody detects endogenous levels of total PDGFR α protein.
Platelet-derived growth factor receptor α (PDGFRA), also known as cluster of differentiation 140a (CD140a), is encoded by the gene mapped to human chromosome 4q12. The encoded protein belongs to the receptor tyrosine kinase gene family.

Immunogen

The antiserum was produced against synthesized peptide derived from human PDGFR alpha.

Immunogen Range: 731-780

Biochem/physiol Actions

Platelet-derived growth factor receptor plays a vital role in the development and maturation of platelets. Platelet-derived growth factor receptor α (PDGFRA) acts as a potential target for imatinib, a revolutionary drug for the treatment of chronic myeloid leukemia. PDGFRA pathway might be involved in developmental process of thrombocytes. The encoded protein facilitates hepatic stellate cell (HSCs) proliferation and migration. Mutation in the gene has been observed in gastrointestinal stromal tumors (GISTs).

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Anti-PDGFR α antibody produced in rabbit affinity isolated antibody

Sigma-Aldrich

SAB4502139

Anti-PDGFR α antibody produced in rabbit

Anti-PDGFR α antibody produced in rabbit affinity isolated antibody

Sigma-Aldrich

SAB4502142

Anti-PDGFR α antibody produced in rabbit

Anti-PDGF Receptor β antibody produced in rabbit affinity isolated antibody

Sigma-Aldrich

SAB4502149

Anti-PDGF Receptor β antibody produced in rabbit

Anti-phospho-PDGFRa (pTyr849) antibody produced in rabbit affinity isolated antibody

Sigma-Aldrich

SAB4301412

Anti-phospho-PDGFRa (pTyr849) antibody produced in rabbit

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

-

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Gene Information

human ... PGFRA(5156)

Gene Information

human ... PDGFRA(5156)

Gene Information

human ... PDGFRB(5159)

Gene Information

human ... PDGFRA(5156)

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
210968

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PDGFR? promoter polymorphisms and expression patterns influence risk of development of imatinib-induced thrombocytopenia in chronic myeloid leukemia: A study from India
Guru S A, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 39(10) (2017)
Platelet-Derived Growth Factor Receptor ? Contributes to Human Hepatic Stellate Cell Proliferation and Migration.
Kikuchi A, et al.
The American Journal of Pathology, 187(10), 2273-2287 (2017)
PDGFRA Mutations in Gastrointestinal Stromal Tumors: Frequency, Spectrum and In Vitro Sensitivity to Imatinib
Corless C L, et al.
Journal of Clinical Oncology, 23(23), 5357-5364 (2005)
View All Related Papers

Global Trade Item Number

SKUGTIN
SAB4502139-100UG04061837745171

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