SAE0003
4-Hydroxyphenylpyruvate Dioxygenase from Streptomyces avermitilis
recombinant, expressed in E. coli
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| Size/SKU | Availability | Price |
|---|---|---|
1 mg | Check Cart for Availability | $370.00 |
About This Item
Specific activity:
≥5 U/mg
Recombinant:
expressed in E. coli
$370.00
Check Cart for Availability
recombinant
expressed in E. coli
Quality Segment
form
liquid
specific activity
≥5 U/mg
mol wt
~41.8 kDa
shipped in
dry ice
storage temp.
−70°C
General description
4-Hydroxyphenylpyruvate Dioxygenase (4-HPPD) is a key enzyme in the catabolism of tyrosine and phenylalanine. 4-HPPD catalyzes the synthesis of homogenistate (2,5-dihydroxyphenylacetate) from ρ-hydroxyphenylpyruvate and molecular oxygen. 4-HPPD also catalyzes the conversion of α-ketoisocaproate to Β-hydroxyisovalerate. 4-HPPD requires Fe2+ as an essential cofactor.
Rat 4-HPPD has a minimum of 80% homology with human 4-HPPD. Rat 4-HPPD is expressed abundantly in hepatocytes. It is also expressed in kidney, particularly in epithelial cells of the proximal tubules and the distant tubules. 4-HPPD has been identified as a potential biomarker of drug-induced liver injury in rat studies.
Rat 4-HPPD has a minimum of 80% homology with human 4-HPPD. Rat 4-HPPD is expressed abundantly in hepatocytes. It is also expressed in kidney, particularly in epithelial cells of the proximal tubules and the distant tubules. 4-HPPD has been identified as a potential biomarker of drug-induced liver injury in rat studies.
Other Notes
One unit will oxidize 1 μmole of molecular oxygen per minute at pH 7.0, 25 °C, in the presence of 4-hydroxyphenylpyruvate.
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This Item | |||
|---|---|---|---|
| description recombinant, expressed in E. coli | description lyophilized powder, ≥3 units/mg solid | description chromatographically purified, lyophilized powder, free of DNA contaminants, suitable for Microbiome research | description - |
| specific activity ≥5 U/mg | specific activity ≥3 units/mg solid | specific activity >200 USP units/mg solid | specific activity - |
| recombinant expressed in E. coli | recombinant - | recombinant - | recombinant - |
| form liquid | form lyophilized powder | form - | form liquid |
| storage temp. −70°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| mol wt ~41.8 kDa | mol wt ~700 kDa | mol wt - | mol wt - |
| shipped in dry ice | shipped in dry ice | shipped in dry ice | shipped in wet ice |
Storage Class
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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