SAE0192
Parathyroid Hormone (1-84) Human
Recombinant expressed in E. coli
Synonym(s):
PTH, Parathormone
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About This Item
NACRES:
NA.77
UNSPSC Code:
12352200
Biological source:
Escherichia coli
Form:
solid
Assay:
≥95% (SDS-PAGE)
Pricing and availability is not currently available.
biological source
Escherichia coli
Quality Segment
recombinant
expressed in E. coli
assay
≥95% (SDS-PAGE)
form
solid
shipped in
ambient
storage temp.
−20°C
General description
Parathyroid hormone (PTH), or parathormone, is secreted by the parathyroid glands as a polypeptide containing 84 amino acids. It acts to increase the concentration of calcium in the blood, whereas calcitonin (a hormone produced by the parafollicular cells of the thyroid gland) acts to decrease calcium concentration.
Parathyroid Hormone 1-84 (full length) Human Recombinant produced in E. coli is a single, non-glycosylated, polypeptide chain containing 84 amino acids (MW of ∼9.4kDa) with the following amino acid sequence:
SVSEIQLMHN LGKHLNSMER VEWLRKKLQD VHNFVALGAP LAPRDAGSQR PRKKEDNVLV ESHEKSLGEA DKADVNVLTK AKSQ
Parathyroid Hormone 1-84 (full length) Human Recombinant produced in E. coli is a single, non-glycosylated, polypeptide chain containing 84 amino acids (MW of ∼9.4kDa) with the following amino acid sequence:
SVSEIQLMHN LGKHLNSMER VEWLRKKLQD VHNFVALGAP LAPRDAGSQR PRKKEDNVLV ESHEKSLGEA DKADVNVLTK AKSQ
Biochem/physiol Actions
PTH acts to increase the concentration of calcium in the blood by acting upon parathyroid hormone receptor in three parts of the body: In the bones- It enhances the release of calcium from the large reservoir contained in the bones. Bone resorption is the normal destruction of bone by osteoclasts, which are indirectly stimulated by PTH. Recombinant Human full length PTH 1-84 has potential as an anti-osteoporotic agent, due to its properties as a bone formation stimulant, it increases bone turnover, stimulating osteoblasts and reducing both vertebral and non-vertebral fractures.
Physical form
The product is supplied as lyophilized powder, from a 0.2μm filtered concentrated solution in PBS pH7.4.
Preparation Note
It is recommended to reconstitute the lyophilized PTH in sterile purified water, at not less than 100 μg/ml, which can then be further diluted to other aqueous solutions.
Upon reconstitution PTH should be stored at 2-8 °C up to 7 days and for future use at -20°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid freeze-thaw cycles
Upon reconstitution PTH should be stored at 2-8 °C up to 7 days and for future use at -20°C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid freeze-thaw cycles
Disclaimer
This product is for R&D use only, not for drug, household, or other uses. Please consult the Material Safety Data Sheet for information regarding hazards and safe handling practices.
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This Item | |||
|---|---|---|---|
| description Recombinant expressed in E. coli | description ≥92% (HPLC), powder | description ≥97% (HPLC), powder | description ≥95% (HPLC), powder |
| biological source Escherichia coli | biological source synthetic (organic) | biological source - | biological source - |
| recombinant expressed in E. coli | recombinant - | recombinant - | recombinant - |
| assay ≥95% (SDS-PAGE) | assay ≥92% (HPLC) | assay ≥97% (HPLC) | assay ≥95% (HPLC) |
| Quality Level 100 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| form solid | form powder | form powder | form powder |
| storage temp. −20°C | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
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