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SCP0108

Cathepsin B Substrate

≥95% (HPLC), lyophilized

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10 mg
Usually ships in 2 weeks.
$135.00

About This Item

Empirical Formula (Hill Notation):
C26H36N10O6
Molecular Weight:
584.63
UNSPSC Code:
12352204
NACRES:
NA.32

$135.00

Usually ships in 2 weeks.
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Product Name

Cathepsin B Substrate, colorimetric,

assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥80%

storage condition

protect from light

storage temp.

−20°C

General description

Cathepsin B, a bilobal protein, belongs to the papain-like family of cysteine proteases. It is produced as a preproenzyme. Its catalytic site is present at the interface between the two lobes. Cathepsin B has an occluding loop. It is located in the secretory vesicles of the neuronal cells. Active cathepsin B is found in the endosomal or lysosomal compartment under normal physiological conditions.

Biochem/physiol Actions

Cathepsin B possesses endopeptidase and exopeptidase activity. Active cathepsin B is mostly engaged in intracellular and extracellular protein turnover, which helps cells maintain homeostatic metabolic activity. It also participates in the regulation of pro-hormone and pro-enzyme activation, antigen processing, inflammatory reactions against antigens, tissue remodeling, and apoptosis. Cathepsin B plays a key role in acute pancreatitis. It also plays a vital role in lipid metabolism in atherosclerosis.
Cathepsin B is a lysosomal cysteine proteinase that metabolizes important molecules such as β-amyloid precursor protein into harmless fragments. Cathepsin B may be detected using the chromogenic substrate Z-Arg-Arg-pNA (z-arg-arg-p-nitroanalide) or flourogenic substrate Z-Arg-Arg-AMC (z-Arg-Arg-amino-4-methylcoumarin).

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This Item
SCP0109219392219399
Cathepsin B Substrate, colorimetric

Sigma-Aldrich

SCP0108

Cathepsin B Substrate, colorimetric

Cathepsin D Substrate

Sigma-Aldrich

SCP0109

Cathepsin D Substrate

Cathepsin B Substrate III, Fluorogenic Sensitive fluorogenic substrate for the quantitative determination of cathepsin B activity.

Sigma-Aldrich

219392

Cathepsin B Substrate III, Fluorogenic

Cathepsin D Substrate I Useful as a substrate for the determination of cathepsin D activity.

Sigma-Aldrich

219399

Cathepsin D Substrate I

description

-

description

-

description

Sensitive fluorogenic substrate for the quantitative determination of cathepsin B activity.

description

Useful as a substrate for the determination of cathepsin D activity.

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

form

lyophilized

form

lyophilized

form

lyophilized solid

form

lyophilized solid

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage condition

protect from light

storage condition

protect from light

storage condition

OK to freeze, desiccated, protect from light

storage condition

OK to freeze, desiccated, protect from light

composition

Peptide Content, ≥80%

composition

Peptide Content, ≥85%

composition

-

composition

-

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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