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SCP0193

MMP Substrate

≥95% (HPLC), lyophilized

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Synonym(s):

FS-6

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1 mg
Usually ships in 2 weeks.
$219.00

About This Item

Empirical Formula (Hill Notation):
C55H80N16O16
Molecular Weight:
1221.32
UNSPSC Code:
12352200
NACRES:
NA.32

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Product Name

MMP Substrate,

assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥75%

storage condition

protect from light

storage temp.

−20°C

General description

Matrix Metalloproteases (MMPs) belongs to the zinc metalloprotease family M10. They are zinc-dependent, calcium-containing hydrolases.

Biochem/physiol Actions

Matrix Metalloproteases (MMPs) are involved in extracellular matrix (ECM) degradation. MMPs regulate cellular and disease processes. They are implicated in processes such as cell proliferation, migration, differentiation, angiogenesis, anti-inflammatory response, vasoconstriction, apoptosis and host defense. Dysregulation of MMP is associated with arthritis, ulcers, encephalomyelitis and cancer.
The peptide MCA-Lys-Pro-Leu-Gly-Leu-DNP-Dpa-Ala-Arg-NH2, or FS-6, is a fluorogenic substrate for several matrix metalloproteinases (MMPs). FS-6 is a water-soluble, modified form of the well-established MMP substrate FS-1, where a lysine residue has been added to the N-terminus of FS-1. The resulting FS-6 has been reported to give a peptide with improved kinetic properties for several MMPs, including MMP-1, MMP-8, MMP-13, and MMP-14, compared to FS-1. This MMP substrate has also been described as a particularly useful substrate for the zinc metalloproteinase tumor necrosis factor-α converting enzyme (TACE or ADAM-17). FS-6 can be used to measure metalloproteinase activity in tissue culture conditions, for example, on the surface of viable cells in situ.

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This Item
SCP0192444212SCP0188
MMP Substrate

Sigma-Aldrich

SCP0193

MMP Substrate

MMP 2 Substrate, fluorogenic

Sigma-Aldrich

SCP0192

MMP 2 Substrate, fluorogenic

MMP-2 Substrate, Fluorogenic A quenched fluorescence substrate for MMP-2 (gelatinase A; kcat/Km = 3.97 x 10⁵ M⁻¹s⁻¹).

Sigma-Aldrich

444212

MMP-2 Substrate, Fluorogenic

MMP 8 Substrate ≥95% (HPLC)

Sigma-Aldrich

SCP0188

MMP 8 Substrate

description

-

description

-

description

A quenched fluorescence substrate for MMP-2 (gelatinase A; kcat/Km = 3.97 x 10⁵ M⁻¹s⁻¹).

description

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

assay

≥95% (HPLC)

form

lyophilized

form

lyophilized

form

lyophilized solid

form

lyophilized

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage condition

protect from light

storage condition

protect from light

storage condition

desiccated, protect from light, OK to freeze

storage condition

protect from light

composition

Peptide Content, ≥75%

composition

Peptide Content, ≥73%

composition

-

composition

Peptide Content, ≥80%

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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    Certificates of Analysis (COA)

    Lot/Batch Number
    E257133
    MM0941

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