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SML0005

Cerivastatin sodium salt hydrate

≥98% (HPLC), HMG-CoA reductase inhibitor, powder

Synonym(s):

(3R,5S,6E)-7-[4-(4-Fluorophenyl)-5-(methoxymethyl)-2,6-bis(1-methylethyl)-3-pyridinyl]-3,5-dihydroxy-6-heptenoic acid sodium salt hydrate, Rivastatin hydrate

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$178.00
25 mg

Available to ship TODAYfromMILWAUKEE

$712.00
$605.20

About This Item

Empirical Formula (Hill Notation):
C26H33FNNaO5 · xH2O
CAS Number:
143201-11-0
Molecular Weight:
481.53 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
329825082
NACRES:
NA.77
MDL number:
MFCD20488047
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated

$178.00

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Product Name

Cerivastatin sodium salt hydrate, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D +18 to +26° in ethanol

storage condition

desiccated

color

white to tan

solubility

H2O: ≥5 mg/mL

originator

Bayer

storage temp.

2-8°C

SMILES string

O.[Na+].COCc1c(nc(C(C)C)c(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)c1-c2ccc(F)cc2)C(C)C

InChI

1S/C26H34FNO5.Na.H2O/c1-15(2)25-21(11-10-19(29)12-20(30)13-23(31)32)24(17-6-8-18(27)9-7-17)22(14-33-5)26(28-25)16(3)4;;/h6-11,15-16,19-20,29-30H,12-14H2,1-5H3,(H,31,32);;1H2/q;+1;/p-1/b11-10+;;/t19-,20-;;/m1../s1

InChI key

NJHMEKXCHXHQPP-PZLZTSNUSA-M

General description

Cerivastatin sodium salt hydrate belongs to the statin class of lipid lowering agents. It helps in decreasing MAP kinase activation, blocking AP-1 (activator protein-1) and NF-kB (nuclear factor-kB ) binding activity, inhibiting inflammatory responses and ameliorated renal damage. It also lowers cholesterol. It is metabolized by cytochrome P450 (CYP)3A4 and (CYP)2C8. Cerivastatin sodium salt hydrate is linked to rhabdomyolysis.

Application

Cerivastatin sodium salt hydrate may be used in cell signaling studies.
Cerivastatin sodium salt hydrate has been used as a supplement in cell culture.

Biochem/physiol Actions

Cerivastatin sodium is an HMG-CoA reductase inhibitor. HMG-CoA is a key enzyme in the production of cholesterol.
HMG-CoA reductase inhibitor
Accumulated macrophages in atherosclerotic plaques result in plaque rupture and thrombus formation. Cerivastatin suppresses the growth of macrophages and decreases the expression of matrix metalloproteinases and tissue factor molecules, thus reduces acute coronary events.

Features and Benefits

This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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This Item
P4498SML0038P0039
Cerivastatin sodium salt hydrate ≥98% (HPLC)

Sigma-Aldrich

SML0005

Cerivastatin sodium salt hydrate

Pravastatin sodium salt hydrate ≥98% (HPLC), powder

Sigma-Aldrich

P4498

Pravastatin sodium salt hydrate

Fluvastatin sodium hydrate ≥98% (HPLC)

Sigma-Aldrich

SML0038

Fluvastatin sodium hydrate

PHPS1 sodium salt hydrate ≥98% (HPLC)

Sigma-Aldrich

P0039

PHPS1 sodium salt hydrate

description

≥98% (HPLC)

description

≥98% (HPLC), powder

description

≥98% (HPLC)

description

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

solid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage condition

desiccated

storage condition

-

storage condition

desiccated

storage condition

desiccated

solubility

H2O: ≥5 mg/mL

solubility

H2O: >10 mg/mL

solubility

H2O: ≥9 mg/mL

solubility

DMSO: 10 mg/mL, clear (warmed)

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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