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SML0021

PDI inhibitor 16F16

≥98% (HPLC)

Synonym(s):

2-(2-Chloroacetyl)-2,3,4,9-tetrahydro-1-methyl-1H-pyrido[3,4-b]indole-1-carboxylic acid methyl ester, Methyl 2-(2-chloroacetyl)-1-methyl-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-1-carboxylate

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Size/SKUAvailabilityPrice
5 mg

Available to ship TODAYfromMILWAUKEE

$162.00
$168.00
25 mg

Available to ship TODAYfromMILWAUKEE

$640.00

About This Item

Empirical Formula (Hill Notation):
C16H17ClN2O3
CAS Number:
922507-80-0
Molecular Weight:
320.77
NACRES:
NA.77
PubChem Substance ID:
329825093
UNSPSC Code:
12352200
MDL number:
MFCD20134198
Assay:
≥98% (HPLC)
Form:
powder

$168.00

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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: 12 mg/mL, clear

storage temp.

2-8°C

SMILES string

COC(=O)C1(C)N(CCc2c1[nH]c3ccccc23)C(=O)CCl

InChI

1S/C16H17ClN2O3/c1-16(15(21)22-2)14-11(7-8-19(16)13(20)9-17)10-5-3-4-6-12(10)18-14/h3-6,18H,7-9H2,1-2H3

InChI key

BCSIRYFYAKLJDK-UHFFFAOYSA-N

Application

PDI inhibitor 16F16 may be used in protein disulfide isomerase-mediated cell signaling studies.
PDI inhibitor 16F16 has been used to inhibit PDI (protein disulfide isomerase) function to examine the functional conservation of PDIs in human embryonic kidney cells.

Biochem/physiol Actions

16F16 is a protein disulfide isomerase (PDI) inhibitor, first identified in a screen for compounds that prevent apoptosis induced by mutant huntingtin protein. 16F16 not only suppressed apoptosis induced by the misfolded protein mutant hungtingtin, it also protected rat neurons from cell death triggered by Aβ peptide. The actions of this inhibitor helped to identify a new mechanism in which a cell death pathway is regulated by protein misfolding via PDI upregulation.
Protein disulfide isomerase (PDI) inhibitor; suppresses apoptosis induced by misfolded proteins

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PDI inhibitor 16F16 ≥98% (HPLC)

Sigma-Aldrich

SML0021

PDI inhibitor 16F16

1S,3R-RSL 3 ≥98% (HPLC)

Sigma-Aldrich

SML2234

1S,3R-RSL 3

NHI-2 ≥98% (HPLC)

Sigma-Aldrich

SML1463

NHI-2

trans-Ned-19 ≥98% (HPLC)

Sigma-Aldrich

SML2830

trans-Ned-19

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

description

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

solubility

DMSO: 12 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

solubility

DMSO: 20 mg/mL, clear

solubility

DMSO: 2 mg/mL, clear

color

white to tan

color

white to beige

color

white to beige

color

white to beige

Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

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