Skip to Content
MilliporeSigma

Key Documents

View All Documentation

Skip To

SML0055

Securinine

≥98% (HPLC)

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Size/SKUAvailabilityPrice
25 mg
Check Cart for Availability
$279.00

About This Item

Empirical Formula (Hill Notation):
C13H15NO2
CAS Number:
5610-40-2
Molecular Weight:
217.26
UNSPSC Code:
12352200
PubChem Substance ID:
329825122
MDL number:
MFCD00078775
Assay:
≥98% (HPLC)
Form:
powder

$279.00

Check Cart for Availability
​
Request a Custom Order
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Quality Segment

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D -980 to -1015 (C=1, MeOH)

color

yellow

solubility

DMSO: ≥25 mg/mL

storage temp.

2-8°C

SMILES string

O=C1O[C@@]23C[C@@H](C=CC2=C1)N4CCCC[C@H]34

InChI

1S/C13H15NO2/c15-12-7-9-4-5-10-8-13(9,16-12)11-3-1-2-6-14(10)11/h4-5,7,10-11H,1-3,6,8H2/t10-,11-,13+/m1/s1

InChI key

SWZMSZQQJRKFBP-WZRBSPASSA-N

Application

Securinine was used as a standard in the synthesis of the members of Securinega alkaloid family.

Biochem/physiol Actions

Securinine is a GABAA receptor antagonist which has been found to increase p73 protein expression
Securinine is an alkaloid widely in traditional folk medicine. Long known as a GABAA antagonist, securinine was recently found to up-regulate p53 protein and to modulate the related family member p73 protein in a p53-dependent fashion, inducing p73 in the HCT116 p53(-) cells and down-regulating it in the p53(+) cells. Induction of proapoptotic protein p73 only in p53 cells could be used to target cancer cells preferentially. Securinine has been found to induce p53-independent, p73-dependent apoptosis in RKO colon cancer cells.

Features and Benefits

This compound is featured on the GABAA Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
PHL85771PHR1627BP1167
Securinine ≥98% (HPLC)

Sigma-Aldrich

SML0055

Securinine

Securinine phyproof® Reference Substance

PHL85771

Securinine

Vecuronium Bromide Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1627

Vecuronium Bromide

Vecuronium bromide British Pharmacopoeia (BP) Reference Standard

BP1167

Vecuronium bromide

description

≥98% (HPLC)

description

phyproof® Reference Substance

description

Pharmaceutical Secondary Standard; Certified Reference Material

description

British Pharmacopoeia (BP) Reference Standard

form

powder

form

solid

form

-

form

solid

assay

≥98% (HPLC)

assay

≥90.0% (HPLC)

assay

-

assay

-

Quality Level

100

Quality Level

-

Quality Level

300

Quality Level

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: ≥25 mg/mL

solubility

-

solubility

-

solubility

-

color

yellow

color

-

color

-

color

-

Still not finding the right product?

Explore all of our products under Securinine

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Codes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Questions

Reviews

No rating value

Active Filters