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SML0077

VU591

≥98% (HPLC)

Synonym(s):

2,2′-(oxydimethanediyl)bis(5-nitro-1H-benzimidazole), 2,2′-(oxydimethanediyl)bis(6-nitro-1H-benzimidazole), 5-nitro-2-{[(6-nitro-1H-benzimidazol-2-yl)methoxy]methyl}-1H-benzimidazole

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Size/SKUAvailabilityPrice
5 mg
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$125.00

About This Item

Empirical Formula (Hill Notation):
C16H12N6O5
CAS Number:
Molecular Weight:
368.30
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
Assay:
≥98% (HPLC)
Form:
powder

$125.00


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Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: ≥12 mg/mL

storage temp.

2-8°C

SMILES string

[O-][N+](=O)c1ccc2nc(COCc3nc4ccc(cc4[nH]3)[N+]([O-])=O)[nH]c2c1

InChI

1S/C16H12N6O5/c23-21(24)9-1-3-11-13(5-9)19-15(17-11)7-27-8-16-18-12-4-2-10(22(25)26)6-14(12)20-16/h1-6H,7-8H2,(H,17,19)(H,18,20)

InChI key

ZQPXNYLXYNRFNP-UHFFFAOYSA-N

Gene Information

human ... KCNJ1(3758)

Application

VU591 may be used in cell signaling studies.

Biochem/physiol Actions

ROMK (Kir 1.1) inhibitor
VU591 is a Potassium Inwardly-Rectifying Channel (KCNJ1 or ROMK) specific inhibitor (IC50 = 240 nM) that is closely related to VU590. Unlike VU590, VU591 does not inhibit Kir7.1. The compound has a modest effect on Kir6.2/SUR1, causing 17% inhibition at 10 uM.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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This Item
SML0802M1404SML0710
description

≥98% (HPLC)

description

≥95% (HPLC)

description

≥99% (TLC), powder

description

≥98% (HPLC)

assay

≥98% (HPLC)

assay

≥95% (HPLC)

assay

≥99% (TLC)

assay

≥98% (HPLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

300

Quality Level

100

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

DMSO: ≥12 mg/mL

solubility

DMSO: 10 mg/mL, clear

solubility

DMSO: soluble 10 mg/mL (may require heating), H2O: insoluble

solubility

DMSO: 10 mg/mL

color

white to tan

color

white to beige

color

-

color

white to beige


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable



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