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SML0083

GSK 1059615 sodium salt hydrate

Synonym(s):

(5Z)-5-[[4-(4-pyridinyl)-6-quinolinyl]methylene]-2,4-thiazolidinedione sodium salt hydrate

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Size/SKUAvailabilityPrice
50 mg

Available to ship TODAYfromMILWAUKEE

$539.00
$458.15

About This Item

Empirical Formula (Hill Notation):
C18H10N3O2S·Na · xH2O
CAS Number:
Molecular Weight:
355.35 (anhydrous basis)
UNSPSC Code:
12352203
PubChem Substance ID:
NACRES:
NA.44
Form:
powder

$458.15

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form

powder

Quality Segment

color

yellow

solubility

H2O: ≥8 mg/mL

originator

GlaxoSmithKline

storage temp.

2-8°C

SMILES string

O.[Na+].O=C1[N-]C(=O)C(\S1)=C\c2ccc3nccc(-c4ccncc4)c3c2

InChI

1S/C18H11N3O2S.Na.H2O/c22-17-16(24-18(23)21-17)10-11-1-2-15-14(9-11)13(5-8-20-15)12-3-6-19-7-4-12;;/h1-10H,(H,21,22,23);;1H2/q;+1;/p-1/b16-10-;;

InChI key

KKSRFFGUIONCPS-FLPKAINGSA-M

Biochem/physiol Actions

GSK 1059615 is a PI3 Kinase inhbitor
GSK 1059615 is a potent inhibitor of PI3 Kinase. (IC50 = 2 nM)
GSK 1059615 is a phosphatidylinositol-3-kinases (PI3K) inhibitor. GSK 1059615 inhibits proliferation of breast cancer BT474 cells via four different mechanisms that include retinoblastoma 1 (RB1)-mediated cell cycle arrest, elevated forkhead box protein O1 (FOXO) signaling, deduced MYC and transferrin receptor (TFRC) signaling and decreased cellular metabolism. Additionally, GSK 1059615 can suppress cell proliferation by decreasing mitogen-activated protein kinase (MAPK) signaling and imparts sensitivity to phosphoinositide 3-kinase (PI3K) inhibitor in cells resistant to the protein kinase B or AKT inhibitor. GSK 1059615 functions as a druggable target to reduce radiation-induced apoptosis in NCCIT cells. GSK 1059615 has entered clinical trial in patients with solid tumors or lymphoma and refractory malignancies.

Features and Benefits

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item
N183SML0113A9232
description

-

description

≥98% (HPLC)

description

≥97% (HPLC)

description

≥98% (HPLC)

form

powder

form

lyophilized powder

form

powder

form

powder

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

solubility

H2O: ≥8 mg/mL

solubility

H2O: >10 mg/mL

solubility

DMSO: ≥5 mg/mL

solubility

H2O: >10 mg/mL

originator

GlaxoSmithKline

originator

-

originator

-

originator

-

color

yellow

color

, brown to dark red-brown

color

off-white to brown

color

purple


Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable



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